A note on the alkaloid content of Gloriosa Rotbchildiana, O'Brien*

Bryan, J.T.; Lauter, W.M.

doi:10.1002/jps.3030400512

Cited by 6 publications

(2 citation statements)

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“…The seeds are collected in June and July and the corms in July and August, or during flowering time, when they are considered to be the most rich in colchicine, although there is scant experimental evidence for this. Other plants known to contain colchicine are Androcymbium gramineum (Perrot, 1936), Gloriosa superba and species of Merendera (Mehra and Khoshoo, 1951), and Gloriosa Rothchildiana (Bryan and Lauter, 1951).…”

Section: Annals Of the Rheumatic Diseasesmentioning

confidence: 99%

History of the Use of Colchicum and related Medicaments in Gout: With Suggestions for Further Research

Hartung¹

1954

Annals of the Rheumatic Diseases

109

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This brief history of the use of extracts of Colchicum autumnale in the treatment of gout had its origin in some research relative to the metabolism and mode of action of colchicine. It was interesting to review this history in order to develop a background, and thus to learn what ancient authorities and later observers knew about this drug. We shall review the evidence for the identity of certain plants thought by many investigators to be identical with our modern Colchicum autumnale, and which were described by early writers as poisons and later recommended in the treatment of gout; re-emphasize knowledge which has been more or less forgotten but which could be of experimental and practical usefulness to-day; delineate the fluctuations of popularity of colchicum as a treatment for gout during the past 1,500 years; and briefly mention the history of its uses in other fields of research. At the present time colchicine and its derivatives, as well as other mitotic-arresting drugs, are of considerable importance in the field of cancer research. More thoroughly established, however, is the role of colchicine in the treatment of acute attacks of gout, and it is this latter role that concerns us most here.In the preparation of this study we have received invaluable assistance from Professor

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Section: Annals Of the Rheumatic Diseasesmentioning

confidence: 99%

History of the Use of Colchicum and related Medicaments in Gout: With Suggestions for Further Research

Hartung¹

1954

Annals of the Rheumatic Diseases

109

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“…Aus den Knollen der Gloriosen europaischen Ursprungs wurde die Substanz C (2-Demethylcolchicin) isoliert.Das Vorhandensein dieser Substanzen konnte qualitativ auch in einem kleinen Knollenmuster, welches aus dem botanischen Garten in Kalkutta stammte, nachgewiesen werden(11). und Lauter(12) stellten in den Knollen G. Rothchildiana amerikanischer Herkunft Colchicin in einer Gesamtmenge von 0,043% fest. Um eine eingehendere, qualitative und auch quantitative Erforschung der Inhaltsstoffe dieser am meisten verbreiteten Pflanzen, d. h. der direkt in Indien wachsenden Gloriosa superba zu ermoglichen, wurde in der Umgebung von Poona eine groDere Menge Knollen, Blatter und Bliiten gesammelt.…”

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