The paper studies the open-hereditary property of semi-separation axioms and applies it to the study of digital topological spaces such as an n-dimensional Khalimsky topological space, a Marcus-Wyse topological space and so on. More precisely, we study various properties of digital topological spaces related to low-level and semi-separation axioms such as T 1 2 , semi-T 1 2 , semi-T 1 , semi-T 2 , etc. Besides, using the finite or the infinite product property of the semi-T i-separation axiom, i ∈ {1, 2}, we prove that the n-dimensional Khalimsky topological space is a semi-T 2-space. After showing that not every subspace of the digital topological spaces satisfies the semi-T i-separation axiom, i ∈ {1, 2}, we prove that the semi-T iseparation property is open-hereditary, i ∈ {1, 2}. All spaces in the paper are assumed to be nonempty and connected.