A note on alterations of personal orientation in Parkinsonism

Bowen, Florry P.; Burns, Margaret M.; Brady, Eileen M.; Yahr, Melvin D.

doi:10.1016/0028-3932(76)90071-3

Cited by 46 publications

(17 citation statements)

References 12 publications

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“…RPD but not LPD patients have been shown to make more errors than a control group on a personal orientation task (viewer-centered transformation) (Bowen et al 1976). RPD patients were also slower at mentally rotating hands (viewer-centered transformation) than a control group, whereas groups did not differ when mentally rotating alphanumeric stimuli (object-centered transformation); LPD patients were not assessed (Dominey et al 1995).…”

Section: Side-of-presentation Effects On Visuospatial Function In Pdmentioning

confidence: 99%

Parkinson’s Disease as a Disconnection Syndrome

Cronin‐Golomb

2010

Neuropsychol Rev

101

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Parkinson’s disease (PD) is a major neuro-degenerative disorder that is usually considered in terms of midbrain and basal ganglia dysfunction. Regarding PD instead as a disconnection syndrome may prove beneficial to understanding aspects of cognition, perception, and other neuropsychological domains in the disease. PD is usually of unilateral onset, providing evidence of intrahemispheric dissociations and an imbalance in the usual relative strengths of the right and left hemispheres. Hence, in order to appreciate the neuropsychology of PD, it is important to apply to this disease our understanding of hemispheric lateralization effects and within-hemisphere circuitry from brainstem to higher-order association cortex. The focus of this review is on the relevance of PD-related disconnections among subcortical and cortical structures to cognition, perception, emotion, and associated brainstem-based domains such as sleep and mood disturbance. Besides providing information on disease characteristics, regarding PD as a disconnection syndrome allows us to more completely understand normal brain-behavior relations in general.

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Section: Side-of-presentation Effects On Visuospatial Function In Pdmentioning

confidence: 99%

Parkinson’s Disease as a Disconnection Syndrome

Cronin‐Golomb

2010

Neuropsychol Rev

101

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“…Disturbance in frontal systems abilities and set aptitude may be the underlying disturbance accounting for the difficulties manifested by PD patients in memory and performance of visuospatial tasks. [46][47][48][49]59 Language Linguistic function is relatively spared in PD patients. Matison et al56 found that PD patients without overt dementia had naming-test scores one standard deviation below normal controls, but still within the normal range for the test.…”

Section: Abstraction Setaptitude and Frontal Systemsmentioning

confidence: 99%

“…[24][25][26][27]46,51,56,60,76,78,80 Route finding, some aspects of memory dysfunction, and ability to determine vertical-postural and vertical-visual positions, however, have correlated poorly with PD disability. 41,43,46 Within the PD syndrome, dementia severity correlated best with akinesia and least with tremor.23,56,'6,s1 Laterality PD patients may have a lateral predominance to their symptoms and in some cases the PD syndrome is essentially restricted to one side of the body. Several studies assessing the relationship between intellectual deterioration and laterality of involvement found no difference on a variety of neuropsychological tests between PD patients with right brain damage (RBD) and those with left brain damage (LBD).…”

Section: Severi Tymentioning

confidence: 99%

Intellectual Impairment in Parkinson's Disease: Clinical, Pathologic, and Biochemical Correlates

Cummings

1988

J Geriatr Psychiatry Neurol

198

104

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The prevalence of overt dementia in 27 studies representing 4,336 Parkinson's disease (PD) patients was 39.9%. The studies reporting the highest incidence of intellectual impairment (69.9%) used psychologic assessment techniques, whereas studies identifying the lowest prevalence of dementia (30.2%) depended on nonstandardized clinical examinations. Neuropsychologic investigations reveal that PD patients manifest impairment in memory, visuospatial skills, and set aptitude. Language function is largely spared. Intellectual deterioration in PD correlates with age, akinesia, duration, and treatment status. Neuropathologic and neurochemical observations demonstrate that PD is a heterogeneous disorder: the classic subcortical pathology with dopamine deficiency may be complicated by atrophy of nucleus basalis and superimposed cortical cholinergic deficits, and a few patients have the histopathologic hallmarks of Alzheimer's disease. Mild intellectual loss occurs with the classic pathology, and the more severe dementia syndromes have cholinergic alterations or Alzheimer's disease. Thus, PD includes several syndromes of intellectual impairment with variable pathologic and neurochemical correlates.

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“…Additionally, verbal creativity deficits have been seen in ROPD (Drago, Foster, Skidmore, & Heilman, 2009). Those with ROPD show a deficit in mental rotation related to one's self‐view (Bowen, Burns, Brady, & Yahr, 1976; Cronin‐Golomb, 2010). In the clinical domain, those with ROPD have shown differences such as greater apathy (Bogdanova & Cronin‐Golomb, 2012), more severe psychosis (Cubo, 2010), and longer duration of illness associated with greater anxiety and depressive symptoms (Foster et al., 2011).…”

Section: Introductionmentioning

confidence: 99%

Side‐of‐onset of Parkinson's disease in relation to neuropsychological measures

et al. 2016

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BackgroundParkinson's disease (PD) usually emerges with a unilateral side‐of‐onset (left‐onset: LOPD; right‐onset: ROPD; Marinus & van Hilten, 2015) due to an asymmetrical degeneration of striatal dopaminergic neurons (Donnemiller et al., Brain, 135, 2012, 3348). This has led to a body of research exploring the cognitive, neuropsychological, and clinical differences between LOPD and ROPD (e.g., Verreyt et al., Neuropsychology Review, 21, 2011, 405).MethodsThirty ROPD and 14 LOPD cases were drawn from a Boston clinic specializing in PD. Various cognitive and neuropsychological measures were used in an attempt to discover if there were indeed any differences between LOPD and ROPD in this cohort.ResultsFor LOPD, duration of illness was found to be significantly greater than that of ROPD. However, further testing was able to confirm that despite this difference, it was not the cause of the other significant differences found. Furthermore, this increased duration was consistent with a previous study (Munhoz et al., Parkinsonism and Related Disorders, 19, 2013, 77). Performance on the Digit Span Backward (DSB) was found to be significantly poorer in LOPD than ROPD, suggesting compromised executive function in LOPD. Additionally, LOPD had significantly greater anxiety on the DASS Anxiety scales than ROPD. However, unlike Foster et al (Cognitive and Behavioral Neurology, 23, 2010, 4), this increased anxiety could not account for the poorer performance on the DSB for LOPD. Finally, ROPD had significantly greater magical ideation than LOPD, which can be explained by the theory put forth by Brugger and Graves (European Archives of Psychiatry, 247, 1997, 55).ConclusionClear and significant differences between LOPD and ROPD were found within our cohort. LOPD showed greater impairment of working memory, greater anxiety, and greater duration of illness—all independent of one another; whereas, those with ROPD had greater magical ideation, also independent of any other variables.

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A note on alterations of personal orientation in Parkinsonism

Cited by 46 publications

References 12 publications

Parkinson’s Disease as a Disconnection Syndrome

Parkinson’s Disease as a Disconnection Syndrome

Intellectual Impairment in Parkinson's Disease: Clinical, Pathologic, and Biochemical Correlates

Side‐of‐onset of Parkinson's disease in relation to neuropsychological measures

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