A nosocomial outbreak of Crimean-Congo hemorrhagic fever

Parlak, Emine; Ertürk, Ayşe; Koşan, Zahide; Parlak, Mehmet; Özkurt, Zülal

doi:10.5799/ahinjs.02.2015.01.0166

Cited by 10 publications

(9 citation statements)

References 14 publications

(58 reference statements)

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“…LVD responds well to the broad-spectrum antiviral agent ribavirin [ 33 ], while it has been suggested that ribavirin could be useful in the treatment of the South American arenaviral infections [ 62 ] and Crimean Congo haemorrhagic fever [ 63 , 64 ]. However, the latter has not been confirmed and is controversial [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Lassa Virus Disease (LVD) in Nigerian children with fever or fever and convulsions in an endemic area

et al. 2017

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BackgroundConvulsions with fever in children are a common neurologic emergency in the tropics, and determining the contribution of endemic viral infections can be challenging. In particular, there is a dearth of data on the prevalence and clinical differentiation of Lassa virus disease (LVD) in febrile children in endemic areas of Nigeria, which has multiple lineages of the virus. The aim of this study was to determine the prevalence and presentation of LVD in febrile children with and without convulsions.Methodology/Principal findingsThis was a prospective study of consecutive febrile children aged ≥1 month– 15 years admitted to the Children’s Emergency Room of Irrua Specialist Teaching Hospital over a period of 1 year. Febrile children with convulsions (Cases) were compared with those without convulsions (Controls). LVD was defined by the presence of a positive Lassa virus RT-PCR test. Rates were compared between groups using χ2 or Fisher’s exact tests and p <0.05 taken as significant. 373 (40.9%) of 913 admissions had fever. Of these, 108/373 (29%) presented with convulsions. The overall prevalence of LVD was 13/373 (3.5%; 95% CI = 1.9%, 5.7%) in febrile admissions, 3/108 (2.8%) in Cases and 10/265 (3.8%) in Controls [(Odds Ratio (95% Confidence Interval) (OR (95% CI)) of LVD in Cases versus Controls = 0.73 (0.2, 2.7)]. Only vomiting (OR (95% CI) = 0.09 (0.01, 0.70)) and bleeding (OR (95% CI) = 39.56 (8.52, 183.7)) were significantly associated with an increased prevalence of LVD.Conclusions/SignificanceLVD is an important cause of fever, including undifferentiated fever in children in endemic areas, but it is not significantly associated with convulsions associated with fever. Its prevalence, and lack of clinical differentiation on presentation, underscores the importance of a high index of suspicion in diagnosis. Screening of febrile children with undifferentiated fever in endemic areas for LVD could be an important medical and public health control measure.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Lassa Virus Disease (LVD) in Nigerian children with fever or fever and convulsions in an endemic area

et al. 2017

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“…The outcomes were classified using a strict case definition: all confirmed HCW cases had positive serology (IgM or IgG seroconversion) and/or positive PCR results. Thirteen of the cases identified have been reported in two previous publications [8] , [9] . Asymptomatic cases were confirmed by CCHF IgG seroconversion.…”

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confidence: 95%

“…Healthcare personnel are at risk from occupational infections during patient care; the first such cases were described in Pakistan and were later reported from many Eurasian countries [4] , [5] , [6] , [7] , [8] , [9] . Isolated imported cases of CCHF or outbreaks in countries lacking CCHF experience present particular infection control challenges, increased risk to healthcare workers (HCWs), and are associated with increased mortality [6] .…”

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confidence: 99%

Healthcare-associated Crimean-Congo haemorrhagic fever in Turkey, 2002–2014: a multicentre retrospective cross-sectional study

Leblebicioğlu

Sünbül

Güner

et al. 2016

Clinical Microbiology and Infection

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Healthcare-related transmission of Crimean-Congo haemorrhagic fever (CCHF) is a well-recognized hazard. We report a multicentre retrospective cross-sectional study undertaken in Turkey in 2014 in nine hospitals, regional reference centres for CCHF, covering the years 2002 to 2014 inclusive. Data were systematically extracted from charts of all personnel with a reported health care injury/accident related to CCHF. Blood samples were tested for CCHF IgM/IgG by enzyme-linked immunosorbent assay and/or viral nucleic acid detection by PCR after the injury. Fifty-one healthcare-related exposures were identified. Twenty-five (49%) of 51 resulted in laboratory-confirmed infection, with a 16% (4/25) overall mortality. The main route of exposure was needlestick injury in 32/51 (62.7%). A potential benefit of post-exposure prophylaxis with ribavirin was identified.

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“…Following the first cases reported in Pakistan, cases were reported with regard to health services throughout the Middle East. [9][10][11][12] Our country is endemic in terms of CCHF, but in countries where cases are rarely seen, health personnel face an increased risk. [8] These injuries lead to psychiatric problems as much as physical ones that may occur after trauma.…”

Section: Introductionmentioning

confidence: 99%

It Could Have Been Protected but Wasn’t

Şahin¹

2019

Anatol JFM

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This research was carried out retrospectively with the incised wound cases that occurred at the KSU Faculty of Medicine Hospital between January 1 st , 2013 and December 31 st , 2016. Health personnel were examined in terms of gender, professional job position groups, forms of injury, locations of injury, compliance with protective barriers used, and precautions taken. Results: The most frequently injured bodily region was the left hand with 122 (51.2%), followed by the right hand with 104 (43.6%). The most frequent injury took place while recapping to cover the tip of a needle with 86 (36.0%). No type of protective equipments was used for 169 (71.0%) of the health personnel who were included in the study. Conclusion: That there was high noncompliance with the use of protective equipment revealed that health workers needed to be subjected to certain, periodic training. In addition to this, the care for injuries and the provision of training in which the infection control committee needed to be referred to in situations of injury was brought to the forefront.

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A nosocomial outbreak of Crimean-Congo hemorrhagic fever

Cited by 10 publications

References 14 publications

Prevalence of Lassa Virus Disease (LVD) in Nigerian children with fever or fever and convulsions in an endemic area

Prevalence of Lassa Virus Disease (LVD) in Nigerian children with fever or fever and convulsions in an endemic area

Healthcare-associated Crimean-Congo haemorrhagic fever in Turkey, 2002–2014: a multicentre retrospective cross-sectional study

It Could Have Been Protected but Wasn’t

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