A nonpolymorphic class I gene in the murine major histocompatibility complex

Mellor, Andrew L.; Weiß, Elisabeth H.; M, Kress; Jay, Gilbert; Flavell, Richard A.

doi:10.1016/0092-8674(84)90082-5

Cited by 145 publications

(106 citation statements)

References 20 publications

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“…The majority of the Q genes has been sequenced now: Q4 [16], Q7 [4,17], Q8 and Q9 [ 17], and Q10 [ 18]. It was not surprising to learn that these genes display the same organization as the H-2K and H-2D genes.…”

Section: The Structure Of Q Region Genesmentioning

confidence: 99%

“…The Q10 gene codes for a stop codon in the same position as in the even-numbered counter- parts Q4 and Q8, which here is the result of a 13-base pair deletion encompassing the triplets 291 to 294 [18]. This deletion has a more profound effect on the encoded pro tein structure.…”

Section: The Structure Of Q Region Genesmentioning

confidence: 99%

“…It not only drastically re duces the transmembrane domain, but even abolishes the hydrophobic structure of this domain due to a frame shift. The un usual exon 5 sequence has suggested that the QIO encodes a secreted class I antigen [18,21].…”

Section: The Structure Of Q Region Genesmentioning

confidence: 99%

“…A comparison of the Q genes between two mouse strains revealed that allelic sequences are remarkably conserved [16,18]. Even the unusual structures in exon 5 are identical.…”

Section: Allelic Polymorphism Does Not Occur In the Q Regionmentioning

confidence: 99%

“…Q7 and its allele 27.1 show a 99% homology at the DNA level and predict amino acid sequences with only three differences [4,17]. Mellor et al [18] have shown that there is a 99% homology between the Q10 genes of the C57BL/10 (H-2 b ) and SW R/J (H-2") mouse. The H-2D28.5 partial genomic sequence published by Jaulin et al [26] derived from the Balb/c mouse is, except for three base pair changes, identical to the Q4 gene of the BIO mouse [16], thus including the Q4 sequence among the nonpolymorphic Q region genes.…”

Section: Allelic Polymorphism Does Not Occur In the Q Regionmentioning

confidence: 99%

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Molecular biology of the mouse Q region

Weiß

1987

Immunol Res

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Section: The Structure Of Q Region Genesmentioning

confidence: 99%

Section: The Structure Of Q Region Genesmentioning

confidence: 99%

Section: The Structure Of Q Region Genesmentioning

confidence: 99%

“…A comparison of the Q genes between two mouse strains revealed that allelic sequences are remarkably conserved [16,18]. Even the unusual structures in exon 5 are identical.…”

Section: Allelic Polymorphism Does Not Occur In the Q Regionmentioning

confidence: 99%

Section: Allelic Polymorphism Does Not Occur In the Q Regionmentioning

confidence: 99%

See 3 more Smart Citations

Molecular biology of the mouse Q region

Weiß

1987

Immunol Res

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SingleH2Kb, H2Db and doubleH2KbDb knockout mice: peripheral CD8+ T cell repertoire and antilymphocytic choriomeningitis virus cytolytic responses

Pérarnau¹,

Saron²,

et al. 1999

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Single H2K b , H2D b and double H2K b D b homozygous knockout (KO) mice were generated and their peripheral CD8 + T cell repertoires compared to that of C57BL/6 (B6) mice. Limited (10-20 %, H2D b), substantial (30-50 %, H2K b) and profound (90 %, H2K b D b) reduction of peripheral CD8 + T cells was observed in KO mice, without V g diversity alteration. Classical class Ia molecules therefore ensure most but not all of the peripheral CD8 + T cell repertoire education. As expected, H2K b but also H2D b KO mice developed choriomeningitis following intracranial infection by lymphocytic choriomeningitis virus with the same kinetics, lethality and CD8 + cell implication as wild-type B6 mice. By contrast, H2K b D b (class Ia-Ib +) KO mice survived. Choriomeningitis of H2D b KO mice was linked to the development of a subdominant (in normal B6 mice) H2K b-restricted cytotoxic T lymphocyte response. Mice expressing a restricted set of histocompatibility class I molecules should represent useful tools to evaluate the immunological potentials of individual MHC class I molecules.

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A new cell surface molecule closely related to mouse class i transplantation antigens

et al. 1989

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The "37" H-2 class I mouse gene, located in the Tla complex, is poorly polymorphic and is transcribed in a wide variety of cells and tissues. Using antisera directed against peptides deduced from the gene sequence, we demonstrate that the 37 gene encodes a 45.5-kDa cell surface glycoprotein. This protein, initially identified on the surface of mouse L cells transfected with an overexpressing 37 gene, is present on cells such as splenocytes of various mouse strains except those of A/J mice. Thus, mouse cells may express not only the major transplantation antigens encoded by the K and D region genes, but at least one additional poorly polymorphic class I molecule encoded by the 37 gene.

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A nonpolymorphic class I gene in the murine major histocompatibility complex

Cited by 145 publications

References 20 publications

Molecular biology of the mouse Q region

Molecular biology of the mouse Q region

SingleH2Kb, H2Db and doubleH2KbDb knockout mice: peripheral CD8+ T cell repertoire and antilymphocytic choriomeningitis virus cytolytic responses

A new cell surface molecule closely related to mouse class i transplantation antigens

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