2017
DOI: 10.1089/clinomi.04.04.16
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A Noninvasive Future: Prenatal Genetic Testing Looks to Single-Cell Methods as the Next Frontier

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“…In most recent studies after an initial enrichment step, the enriched cell fraction is spread on a slide and automated microscopy coupled with laser capture microdissection or micropipette aspiration is used to obtain single fetal cell. The performance of the initial enrichment step is critical as high levels of fetal cell recovery/white blood cell (WBC) depletion would allow for better clinical scalability and therefore relevance . The reliance on laser capture microdissection to obtain the fetal cells adds significant complexity, cost, and scalability issues to such processes thus hindering the translation into clinics.…”
Section: Introductionmentioning
confidence: 99%
“…In most recent studies after an initial enrichment step, the enriched cell fraction is spread on a slide and automated microscopy coupled with laser capture microdissection or micropipette aspiration is used to obtain single fetal cell. The performance of the initial enrichment step is critical as high levels of fetal cell recovery/white blood cell (WBC) depletion would allow for better clinical scalability and therefore relevance . The reliance on laser capture microdissection to obtain the fetal cells adds significant complexity, cost, and scalability issues to such processes thus hindering the translation into clinics.…”
Section: Introductionmentioning
confidence: 99%