A non-randomized comparative study of olfactory and gustatory functions in children who recovered from COVID-19 (1-year follow-up)

Намазова-баранова, Л. С.; Karkashadze, G.A.; Zelenkova, Irina V.; Вишнева, Е.А.; Kaytukova, Elena; Русинова, Д. С.; Устинова, Н. В.; Sergienko, N. V.; Nesterova, Yulia; Yatsyk, Leonid; Kratko, Dmitrii; Gubanova, Svetlana G.; Ганковский, В. А.; Гогберашвили, Т. Ю.; Konstantinidi, Tatiana A.; Bushueva, Darya; Rykunova, Anastasia; Sadilloeva, Svetlana; Sergeeva, Natalia E.; Lamasova, Anastasia; Leonova, Elizaveta V.; Pankova, Alina; Dubonosova, Ekaterina

doi:10.3389/fped.2022.919061

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…After one year, a re-examination of 21 children showed that the sensitivity to odorants increased significantly. Furthermore, the thresholds of smell in children who were infected with SARS-CoV-2 and those who were not, revealed that olfactory sensitivity in children can be restored to normal values [86].…”

Section: Multisystem Inflammatory Syndrome In Children (Mismentioning

confidence: 97%

The course of COVID-19 in pediatric patients – specific and non-specific clinical manifestations

Januszewski,

Tobiasz,

Tyczyńska

et al. 2023

J Pre Clin Clin Res.

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Introduction and Objective. COVID-19 caused by SARS-CoV 2 is a still serious danger. The disease which triggered off the COVID-19 pandemic and one of the biggest health crises in many years, began in the city of Wuhan, China, in 2019. The aim of this review is to distinguish most of the specific and non-specific manifestations of the disease among children. Review Methods. The literature review was based on different types of articles including reviews, meta-analyses, systemic reviews, and randomized controlled trials on PubMed, Web of Science, and Scopus databases. Key words featured COVID-19, MIS-C, SARS-CoV-2 manifestations, and specific, and non-specific manifestations of COVID-19. The literature search was performed until September 2023, and concerned only paediatric patients. Brief description of the state of knowledge. Research based on already published studies prevents the forming of firm conclusions. There are different symptoms of COVID-19 infection, some of them are typical, mild, and do not concern medical care units. There are also some non-specific manifestations, often related to multisystem inflammatory syndrome in children (MIS-C), which are more severe and sometimes demand involving intensive care units. Conclusions. A large group of infected children with asymptomatic or present mild symptoms of COVID-19. Nonspecific manifestations, such as cardiovascular, gastrointestinal, psychiatric, neurological, ophthalmic, dermatological, or rheumatological symptoms, can potentially be misleading and require more attention.

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Section: Multisystem Inflammatory Syndrome In Children (Mismentioning

confidence: 97%

The course of COVID-19 in pediatric patients – specific and non-specific clinical manifestations

Januszewski,

Tobiasz,

Tyczyńska

et al. 2023

J Pre Clin Clin Res.

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“…Состояние обоняния определялось с помощью ольфактометрии, которая заключалась в определении порога обоняния трех ольфактантов (настойки валерианы, уксусной кислоты, нашатырного спирта) и способности идентификации одоранта с помощью специальной ольфактометрической методики [66,67]. Количественная оценка порога обоняния и идентификационной способности проводилась в баллах согласно указанной методологии.…”

Section: методы измерения целевых показателейunclassified

Levels of Neurospecific Peptides, Neurotransmitters and Neuroreceptor Markers in the Serum of Children with Various Sensory Disorders, Mild Cognitive Impairments and Other Neuropathology

et al. 2023

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Background. The role of recently discovered neurospecific peptides in the pathogenesis of acute and progressive neurologic disorders, their neuroprotective features, and possibilities to use them as markers for the course and prognosis of certain diseases have been actively studied in recent decades. However, neurospecific peptides are almost not studied in chronic residual diseases. In our study we measured the levels of neurospecific peptides and some other markers to achieve understanding of general neurophysiological trends in congenital and acquired chronic non-progressive brain pathology with reference to the selection of relevant groups — study objects. Objective. The aim of the study is to study patterns of neurospecific peptides, neurotransmitters and neuroreceptor markers distribution in the serum of children with various pathogenetic variants of chronic neuropathology. Methods. The study included children from 3 to 16 years old with different pathologies. The sample was divided into groups by pathology type: no sensory and neurological disorders, congenital sensory deficit due to mutation of genes expressed and not expressed in the brain, early acquired sensory deficit of multifactorial nature, congenital mild and severe organic disorders of central nervous system (CNS) in residual stage without baseline sensory deficit, acquired functional CNS disorders without baseline organic defect and sensory deficit. The following laboratory data (neurophysiological components) was studied: nerve growth factor, brain-derived neurotropic factor, neurotrophin-3, neurotrophin-4, neuregulin-1-beta-1, beta-secretase, sirtuin-1, synaptophysin, neuronal nitric oxide synthase, and anti-NR2 glutamate receptor antibodies. The parameters of cognitive activity, sense of vision, sense of smell, and acoustic sense were also evaluated. Results. The study included 274 participants. Neuropeptides and markers have shown a variable degree and range in the group spectrum of differences from normal levels. The most variable in the examined sample was NO-synthase, as well as levels of both neurotrophins, beta-secretase, and glutamate receptor marker. All visual deficits were associated with increased NO-synthase levels (p < 0.001). Neuroplasticity peptides (beta-secretase, neurotrophin-3 and 4) have been activated in all pathological conditions. Nerve growth factor and brain-derived neurotropic factor were specifically activated in mild organic CNS lesions (mild cognitive impairments), while neuregulin — in congenital genetically determined visual deficits. There was no specific activation of neuropeptides and NO-synthase level tended to decrease in cases of severe CNS lesions. Conclusion. The study results suggest that all types of early visual impairment are associated with increased physiological neuronal activity, and non-organic neurological functional disorders — mainly with increased physiological synaptic activity. General neuroplasticity processes were activated in all cases of visual deficits but more specific. However, more specific and well-studied processes were activated in mild organic CNS lesions, and neuroplasticity processes did not activate adequately in severe organic CNS lesions probably due to the limited neuronal and synaptic resources.

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“…Значительный разброс эпидемиологических данных распространенности постковидного синдрома среди детей может быть обусловлен использованием различных критериев диагностики [7]. По данным лонгитюдного исследования, такие проявления постковидного синдрома у детей, как астения, снижение внимания, нарушение обоняния, регистрируемые через 1,5 мес после перенесенной инфекции, разрешаются в течение года [8].…”

Section: обоснованиеunclassified

Post-COVID Syndrome in Children: One-Time Survey Study of Parents’ Opinion

Shagieva

Kutlubaev

Rakhmatullin

2023

Vopr. sovr. pediatr.

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Background. COVID-19 symptoms often persist for a long time, it indicates the post-COVID syndrome development. Its frequency in children population is generally studied by interviewing the children themselves. This approach limits the risk evaluation of post-COVID syndrome development in young children who are unable to describe the persistent symptoms due to their age.Objective. The aim of the study is to evaluate the prevalence of post-COVID syndrome in children and its effect on their daily activities by interviewing parents.Methods. The survey covered parents of children (aged from 3 months to 18 years) who suffered laboratory-confirmed COVID-19 in 2021–2022 but not earlier than 12 weeks before study initiation. The survey was conducted on-line. The presence of the symptoms (persisted or occurred 12 weeks after COVID-19), its impact on children’s daily life, the need for medical treatment or doctor's advice (due to these post-covid symptoms) and vaccination against novel coronavirus infection were evaluated. Incidence of post-COVID syndrome was analyzed in subgroups based on sex, age (< 3 years, 3–6 and 7–17 years), and disease severity.Results. Invitations to participate in the study were sent to 2292 parents of all children registered at the clinic and suffered from COVID-19 via WhatsApp and Telegram messengers. 1533 (66.9%) of them agreed to take part in the survey, and 1258 (54.8%) filled out the questionnaire in full. The survey has revealed that at least one symptom that persisted or occurred 12 weeks after COVID-19 was noted by parents in 764 out of 1258 (60.6%) children (more often in the older age group and in severe cases). Significant negative impact of symptoms on children’s daily life was noted by 251 out of 764 (32.9%) respondents. Parents of 734 out of 764 (96.1%) children have visited a doctor due to post-COVID syndrome symptoms.Conclusion. Post-COVID syndrome develops in more than 60% of children after laboratory-confirmed COVID-19, according to parents. However, we have reasons to believe that parental estimations could overestimate the prevalence of post-COVID syndrome.

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A non-randomized comparative study of olfactory and gustatory functions in children who recovered from COVID-19 (1-year follow-up)

Cited by 5 publications

References 19 publications

The course of COVID-19 in pediatric patients – specific and non-specific clinical manifestations

The course of COVID-19 in pediatric patients – specific and non-specific clinical manifestations

Levels of Neurospecific Peptides, Neurotransmitters and Neuroreceptor Markers in the Serum of Children with Various Sensory Disorders, Mild Cognitive Impairments and Other Neuropathology

Post-COVID Syndrome in Children: One-Time Survey Study of Parents’ Opinion

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