A non-opioid analgesic implant for sustained post-operative intraperitoneal delivery of lidocaine, characterized using an ovine model

Svirskis, Darren; Procter, Georgina; Sharma, Manisha; Bhusal, Prabhat; Dravid, Anusha; MacFater, Wiremu; Barazanchi, Ahmed; Chandramouli, Kaushik; Sreebhavan, Sree; Agarwal, Priyanka; Amirapu, Satya; Hannam, Jacqueline A.; Andrews, Gavin; Hill, Andrew; Jones, David S.

doi:10.1016/j.biomaterials.2020.120409

Cited by 12 publications

(7 citation statements)

References 32 publications

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“…In addition, the continuous infusion of local anesthetics through an indwelling catheter throws the risks of mechanical nerve injury and infections. Over the past few years, research on long-acting local anesthetic development has been focused on three major methods: developing new long-acting local anesthetic, exploring novel assisted adjuvants, and investigating delivery systems with a controlled release manner 39 - 41 . The most widely used drugs, lidocaine, ropivacaine, and bupivacaine, whose anesthetic effects all last less than 8 h 42 .…”

Section: Discussionmentioning

confidence: 99%

Injectable electrospun fiber-hydrogel composite sequentially releasing clonidine and ropivacaine for prolonged and walking regional analgesia

Chen¹,

Yao²,

Wang³

et al. 2022

Theranostics

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Rationale : Peripheral nerve block is a traditional perioperative analgesic method for its precise pain control and low systemic toxicity. However, a single low dose of local anesthetic merely provides a few hours of analgesia, and high dose results in irreversible toxicity, whereas continuous infusion of anesthetics is expensive and complicated. Therefore, it is necessary to develop a long-acting and sensory-selective local anesthetic for safe perioperative analgesia. Methods : An injectable composite comprising ropivacaine-loaded poly (ε-caprolactone) electrospun fiber and clonidine-loaded F127 hydrogel (Fiber-Rop/Gel-Clo composite) was developed for long-acting and walking regional analgesia with barely one dose. The peripheral nerve blockade effect of the composite was evaluated in a rat sciatic nerve block model. Also, the biodegradability and biosafety of the composite was evaluated. Results : The preferentially released Clo from the hydrogel rapidly constricted the peripheral arterial vessels, reducing the blood absorption of Rop and thus enhancing the local Rop accumulation at the injection site. The subsequently sustainable release of Rop from the fiber, significantly prolonged the sciatic nerve block of rats. Remarkably, an amazing sensorimotor segregation effect was achieved, as the sensory blockade (32.0 ± 1.4 h) lasted significantly longer than the motor blockade (20.3 ± 0.9 h). Additionally, the Fiber-Rop/Gel-Clo composite presented good biodegradability and biosafety in vivo . Conclusions : Our designed Fiber-Rop/Gel-Clo composite with minimal invasion, prolonged synergistic analgesia, and strikingly sensorimotor segregation effect, posted a promising prospect for regional long-term walking analgesia in clinical treatment.

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Section: Discussionmentioning

confidence: 99%

Injectable electrospun fiber-hydrogel composite sequentially releasing clonidine and ropivacaine for prolonged and walking regional analgesia

Chen¹,

Yao²,

Wang³

et al. 2022

Theranostics

View full text Add to dashboard Cite

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“…In addition, there are high lymphatic vessels and vascularization, which allows for oxygen and nutrient supply to the transplanted islets [440] . Although these sites are still under early-stage research, the good plasticity, high capacity, and vascular networks make these potential sites for medical device implantation [441] . Kim et al [442] showed that the glycemic control for omentum islet transplantation in mice was better than kidney, liver, and muscle.…”

Section: Transplantation Site and Deliverymentioning

confidence: 99%

Type 1 diabetes and engineering enhanced islet transplantation

Jeyagaran

Lu²,

Zbinden³

et al. 2022

Advanced Drug Delivery Reviews

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“…To address these critical issues, more drug carriers have been rationally built to realize controllable and sustainable drug release [5] with the advancement of nanotechnology. Various forms of nanocarriers such as hollow mesoporous organosilica nanoparticles (HMONs), [6] hydrogels, [7] liposomes, [8] polymeric formulation, [9,10] and metal nanoparticles [11] have been designed, providing a promising strategy to optimize the pharmacokinetic profile of drugs without modifying their chemical structure. We have constructed a nanocarrier based on organic-inorganic hybrid HMONs-based nanoplatforms.…”

Section: Introductionmentioning

confidence: 99%

Engineering 2D Silicene‐Based Mesoporous Nanomedicine for In Vivo Near‐Infrared‐Triggered Analgesia

Yin

Gao

et al. 2022

Advanced Science

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The utilization of local anesthetics for postoperative analgesia represents an effective approach, but generally suffers from short half‐lives and brachychronic local neurotoxicity. A desirable anesthetic with controllable and sustainable drug‐releasing performance for adequate analgesia effect is highly required. In this work, the core/shell‐structured two‐dimenional (2D) silicene nanosheets coated with mesoporous silica layer (abbreviated as Silicene@MSNs) have been rationally constructed as localized drug‐delivery system in sciatic nerve block to achieve on‐demand release of loaded ropivacaine (RP) in mesoporous silica layer for local analgesia. Based on the specific photothermal performance of 2D silicene core, this local anesthesia system can be triggered by near‐infrared laser to release the loaded RP, resulting in on‐demand and long‐lasting regional anesthesia. The analgesia effect is assessed by pain behavior tests, which demonstrates that the RP‐loaded Silicene@MSNs core/shell nanosystem behaves almost five times longer analgesia effect than free RP. Furthermore, the activation of pain‐related neurons in nerve conduction pathways is tested to explore the underlying analgesia mechanism, revealing that the designed nanosystem can improve the pain threshold, reduce the activation of neurons in dorsal root ganglion and excitability in spinal substantia gelatinosa neurons. This designed anesthetic nanomedicine provides a facile but effective methodology for long‐lasting regional anesthesia.

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A non-opioid analgesic implant for sustained post-operative intraperitoneal delivery of lidocaine, characterized using an ovine model

Cited by 12 publications

References 32 publications

Injectable electrospun fiber-hydrogel composite sequentially releasing clonidine and ropivacaine for prolonged and walking regional analgesia

Injectable electrospun fiber-hydrogel composite sequentially releasing clonidine and ropivacaine for prolonged and walking regional analgesia

Type 1 diabetes and engineering enhanced islet transplantation

Engineering 2D Silicene‐Based Mesoporous Nanomedicine for In Vivo Near‐Infrared‐Triggered Analgesia

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