A non-isothiocyanate route to synthesize trisubstituted thioureas of arylamines using in situ generated dithiocarbamates

Abstract

A non-isothiocyanate route to synthesize trisubstituted thioureas of arylamines using in situ generated dithiocarbamates3

Chromatography‐Free Multicomponent Synthesis of Thioureas Enabled by Aqueous Solution of Elemental Sulfur

“…N ‐(2,6‐Dimethylphenyl)morpholine‐4‐carbothioamide (6 aj) : White solid, m.p. 163–164 °C (water; ref [88] . 138–140 °C); 1 H‐NMR: (500 MHz, CDCl 3 , ref [88] …”

“…[85] ) δ 7.77 (bs, 1H), 7. [87] 184-186°C); 1 H-NMR: (500 MHz, CDCl 3 , ref [87] [88] 138-140°C); 1 H-NMR: (500 MHz, CDCl 3 , ref. [88] ) δ 7.…”

A magnetically recyclable iron oxide-supported copper oxide nanocatalyst (Fe3O4–CuO) for one-pot synthesis of S-aryl dithiocarbamates under solvent-free conditions

“…45 Organic dithiocarbamates have received much attention because of their interesting chemistry and wide range of utilities. They have many potential applications as versatile synthetic intermediates, [46][47][48][49][50][51][52] linkers in solid phase organic synthesis, 53,54 protecting groups in peptide synthesis, 55,56 agrochemicals, [57][58][59] and biologically active compounds. 60,61 They are used in the rubber industry as vulcanization accelerators, 62,63 in medicinal chemistry [64][65][66][67] and recently as single precursor sources for the preparation of nanoparticles.…”

Direct synthesis of carbamates, thiocarbamates, and ureas from Boc-protected amines: a sustainable and efficient approach

“…Acknowledging the paramount bioactivity of these compounds, 19 the development of novel and efficient synthetic methodologies is deemed crucial. Conventional synthesis pathways that rely on phosgene, 20 its derivatives, 21,22 and transition metal catalysts (including palladium, 23 nickel, 24,25 and rhodium 26,27 ) are fraught with challenges, notably the use of toxic reagents and the consequential contamination with residual heavy metals.…”