This paper presents a robust hybrid controller for non-inverting buck-boost (NIBB) DC-DC converter. The proposed hybrid controller is comprised of feedback closed-loop PID controller and novel designed feedforward open-loop controller. The proposed open-loop controller supports the PID controller and enhances the system transient response during the system operating parameters transition. The open-loop controller has a simple and static structure. It is also independent of the closed-loop controller and thus has a modular behaviour. In order to show the accuracy, robustness and efficiency of the proposed hybrid control method, both simulation and experimental studies are performed. The comparative results prove that the proposed hybrid controller with the novel developed open-loop controller provides robust and efficient control of the converter. It improves the converter’s output response during the transients of the operating parameters: the change of input voltage, reference output voltage and output load.