A non-invasive wearable stress patch for real-time cortisol monitoring using a pseudoknot-assisted aptamer

Singh, Naveen K.; Chung, Saeromi; Chang, An‐Yi; Wang, Joseph; Hall, Drew A.

doi:10.1016/j.bios.2023.115097

Cited by 29 publications

(18 citation statements)

References 60 publications

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“…Silicon-based microfluidic chips were first developed and have advantages such as high thermal conductivity, special optical properties and electro-osmotic stability. However, their high cost, complex process flow, time consuming nature, rigidity and gas impermeability and other shortcomings have become obstacles to the large-scale application of health monitoring and wearable biomedicine [ 10 , 60 , 62 , 63 , 64 ].…”

Section: Different Materials and Preparation Methods For Microfluidic...mentioning

confidence: 99%

Porous Structural Microfluidic Device for Biomedical Diagnosis: A Review

et al. 2023

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Microfluidics has recently received more and more attention in applications such as biomedical, chemical and medicine. With the development of microelectronics technology as well as material science in recent years, microfluidic devices have made great progress. Porous structures as a discontinuous medium in which the special flow phenomena of fluids lead to their potential and special applications in microfluidics offer a unique way to develop completely new microfluidic chips. In this article, we firstly introduce the fabrication methods for porous structures of different materials. Then, the physical effects of microfluid flow in porous media and their related physical models are discussed. Finally, the state-of-the-art porous microfluidic chips and their applications in biomedicine are summarized, and we present the current problems and future directions in this field.

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Section: Different Materials and Preparation Methods For Microfluidic...mentioning

confidence: 99%

Porous Structural Microfluidic Device for Biomedical Diagnosis: A Review

et al. 2023

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“…For example, recent work reveals that tracking fluctuations in sweat cortisol concentration provides insight into the stress response of the body and the resulting impact on body functions/diseases (Figure 3D 115 ). 114,115,141,142 The potential implications of devices capable of continuously monitoring clinically relevant sweat biomarkers for evaluating the progression or treatment of a variety of diseases are substantial. The need for such technologies is notably exemplified for diabetes.…”

Section: ■ Emerging Applicationsmentioning

confidence: 99%

“…(D) Electrochemical sensor functionalized with a regenerable pseudoknot-assisted aptamer and a flexible microfluidic sweat sampling system to continuously monitor cortisol level fluctuations in sweat. Adapted with permission from ref . Copyright 2023 Elsevier.…”

Section: The Current State Of Sweat Analysismentioning

confidence: 99%

“…Nonenzymatic sensing approaches based upon metals and metal oxides represent an attractive synthetic alternative to circumvent these issues. − Additional avenues for continuous electrochemical sensing include electrochemical aptamer-based (EAB) sensors and molecularly imprinted polymers (MIPs). EAB sensors, which can be regenerated and reused, have demonstrated significant progress in real-time in vivo monitoring in blood but have only recently emerged in sweat sensing. − A notable example is a recent study that achieved continuous on-body cortisol measurements with an EAB sensor, featuring on-body regeneration for extended measurements without necessitating an exchange of the sensing mechanism (Figure D) . MIPs, synthetic receptors that mimic antibody–antigen systems, represent another potential solution for continuous sensing .…”

Section: The Current State Of Sweat Analysismentioning

confidence: 99%

“…Continued advances in sensing capabilities will enable an expanded understanding of the clinical relevance of the time-dynamic and activity-dependent variations of various sweat biomarker concentrations. For example, recent work reveals that tracking fluctuations in sweat cortisol concentration provides insight into the stress response of the body and the resulting impact on body functions/diseases (Figure D). ,,, …”

Section: Emerging Applicationsmentioning

confidence: 99%

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Recent Advances in Skin-Interfaced Wearable Sweat Sensors: Opportunities for Equitable Personalized Medicine and Global Health Diagnostics

Clark,

Ray

2023

ACS Sens.

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Recent advances in skin-interfaced wearable sweat sensors enable the noninvasive, real-time monitoring of biochemical signals associated with health and wellness. These wearable platforms leverage microfluidic channels, biochemical sensors, and flexible electronics to enable the continuous analysis of sweat-based biomarkers such as electrolytes, metabolites, and hormones. As this field continues to mature, the potential of lowcost, continuous personalized health monitoring enabled by such wearable sensors holds significant promise for addressing some of the formidable obstacles to delivering comprehensive medical care in under-resourced settings. This Perspective highlights the transformative potential of wearable sweat sensing for providing equitable access to cutting-edge healthcare diagnostics, especially in remote or geographically isolated areas. It examines the current understanding of sweat composition as well as recent innovations in microfluidic device architectures and sensing strategies by showcasing emerging applications and opportunities for innovation. It concludes with a discussion on expanding the utility of wearable sweat sensors for clinically relevant health applications and opportunities for enabling equitable access to innovation to address existing health disparities.

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Wireless, Flexible, Ionic, Perspiration‐Rate Sensor System with Long‐Time and High Sweat Volume Functions Toward Early‐Stage, Real‐Time Detection of Dehydration

Honda,

Tanaka,

Matsumura

et al. 2023

Adv Funct Materials

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Flexible sensors that can be attached to the body to collect vital data wirelessly enable real‐time, early‐stage diagnosis for human health management. Wearable sweat sensors have received considerable attention for real‐time physiological monitoring. Unlike conventional methods that require blood‐drawing in a clinic, sweat analyses may enable noninvasive tracking of health conditions for early‐stage diagnosis. Even though a variety of studies to monitor metabolites and other substances have been conducted, automatic, continuous, long‐term, simultaneous monitoring of perspiration rate and electrolytes, which are important parameters in dehydration, has yet to be achieved because of challenges related to sensor design. Here a wireless, wearable, integrated, microfluidic sensor system that can continuously measure these parameters in real‐time for prolonged periods are presented. The proposed sensors are systematically characterized, and machine learning is used to predict device tilt angle to calibrate sensor output signals. Using the sensor design to form a water droplet in a fluidic channel, high‐volume perspiration rate is continuously monitored for more than 7000 s (total sweat volume >170 µL). By testing 10 subjects, physiological responses to ingestion of a sports drink are confirmed by measuring perspiration rhythm changes extracted from real‐time, continuous sweat impedance and rate.

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A non-invasive wearable stress patch for real-time cortisol monitoring using a pseudoknot-assisted aptamer

Cited by 29 publications

References 60 publications

Porous Structural Microfluidic Device for Biomedical Diagnosis: A Review

Porous Structural Microfluidic Device for Biomedical Diagnosis: A Review

Recent Advances in Skin-Interfaced Wearable Sweat Sensors: Opportunities for Equitable Personalized Medicine and Global Health Diagnostics

Wireless, Flexible, Ionic, Perspiration‐Rate Sensor System with Long‐Time and High Sweat Volume Functions Toward Early‐Stage, Real‐Time Detection of Dehydration

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