2015
DOI: 10.1042/bj20150336
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A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I

Abstract: Using RNAi, a non-canonical pathway of endosomal sorting complexes required for transport was identified that is responsible for sorting virally ubiquitinated MHC class I into multivesicular bodies (MVBs) during down-regulation of this protein from the cell surface.

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Cited by 40 publications
(45 citation statements)
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“…HD-PTP is an ALIX-like protein that also contains a tyrosine phosphatase domain. In some contexts HD-PTP can replace ALIX in recruiting CHMP4 4143 .…”
Section: The Escrt Machinerymentioning
confidence: 99%
“…HD-PTP is an ALIX-like protein that also contains a tyrosine phosphatase domain. In some contexts HD-PTP can replace ALIX in recruiting CHMP4 4143 .…”
Section: The Escrt Machinerymentioning
confidence: 99%
“…His Domain Protein Tyrosine Phosphatase (HD-PTP) is essential for the lysosomal degradation of multiple membrane receptors, including activated EGFR and PDGFR-β 1 , 2 , MHC Class I 3 and α5β1 integrin 4 . This process requires sorting of the ubiquitinated receptors to intralumenal vesicles (ILVs) within the mutivesicular body (MVB), and their subsequent delivery to the lysosome 5 .…”
Section: Introductionmentioning
confidence: 99%
“…Alix directly regulates ESCRT-III recruitment and assembly at a range of sites 10 , 11 , 21 23 . In contrast, HD-PTP function is largely restricted to MVB biogenesis 1 , 3 .…”
Section: Introductionmentioning
confidence: 99%
“…For example, Alix is a general ESCRT-III regulator that supports multiple ESCRT-dependent processes (Bissig and Gruenberg, 2014, Carlton and Martin-Serrano, 2007, Morita et al., 2007, Schmidt et al., 2004, Sun et al., 2015, von Schwedler et al., 2003). In contrast, HD-PTP function is largely restricted to the early endosome (Doyotte et al., 2008, Parkinson et al., 2015) where it acts in close cooperation with ESCRT-0 (Ali et al., 2013) and UBAP1 (ESCRT-I) to downregulate multiple ubiquitinated cargoes (Agromayor et al., 2012, Kharitidi et al., 2015). UBAP1 is an ubiquitin-binding ESCRT-I subunit that acts exclusively in MVB sorting (Stefani et al., 2011, Wunderley et al., 2014) and, like for HD-PTP (Cheng et al., 1998, Toyooka et al., 2000), haploinsufficiency of UBAP1 is linked to nasopharyngeal carcinoma (Qian et al., 2001).…”
Section: Introductionmentioning
confidence: 99%