“…For example, Alix is a general ESCRT-III regulator that supports multiple ESCRT-dependent processes (Bissig and Gruenberg, 2014, Carlton and Martin-Serrano, 2007, Morita et al., 2007, Schmidt et al., 2004, Sun et al., 2015, von Schwedler et al., 2003). In contrast, HD-PTP function is largely restricted to the early endosome (Doyotte et al., 2008, Parkinson et al., 2015) where it acts in close cooperation with ESCRT-0 (Ali et al., 2013) and UBAP1 (ESCRT-I) to downregulate multiple ubiquitinated cargoes (Agromayor et al., 2012, Kharitidi et al., 2015). UBAP1 is an ubiquitin-binding ESCRT-I subunit that acts exclusively in MVB sorting (Stefani et al., 2011, Wunderley et al., 2014) and, like for HD-PTP (Cheng et al., 1998, Toyooka et al., 2000), haploinsufficiency of UBAP1 is linked to nasopharyngeal carcinoma (Qian et al., 2001).…”