Abstract:The purpose of this study was to devise a simple method to determine whether or not a drug's absorption rate constant favored the selection of that drug for an oral prolonged-release drug delivery system (DDS). Computer simulations were used to observe the drug time-course in the DDS, the gastrointestinal tract, and the cumulative amount absorbed following administration of an 8-, 12-, and 24-hr zero-order DDS. For each DDS, the drug's intrinsic absorption rate constant, ka, was systematically varied from 0.1 … Show more
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