A Nomogram to Better Predict the In-Hospital Mortality of Trauma Patients with Sepsis in the Intensive Care Unit

Abstract

Background. Trauma has a high incidence and mortality worldwide, and sepsis is one of the main causes of mortality in trauma patients. Therefore, it is essential to identify the risk factors of in-hospital mortality for trauma patients with sepsis. Methods. Data were extracted from the Medical Information Mart for Intensive Care III database and divided into a training set and internal validation set, and another Chinese dataset was used as external validation set. Then, risk factors were estimated using univariate and multivariate logistic regression analyses in the training set. Finally, a nomogram was created to predict the probability of in-hospital mortality for trauma patients with sepsis. Results. A total of 503 patients were enrolled in our study (335 in the training set and 168 in the validation set). Multivariate logistic regression analysis revealed that age (1.047 [1.025–1.071]), respiratory rate (1.258 [1.135–1.394]), PTT (1.026 [1.008–1.044]), ventilation (6.703 [1.528–29.408]), and vasopressor use (3.682 [1.502–9.025]) were independent factors associated with in-hospital mortality. The nomogram for trauma-related sepsis predicted in-hospital mortality with AUC values of 0.8939 in the training set, 0.8200 in the internal validation set, and 0.7779 in the external validation set. Conclusions. The new nomogram has a well predicted value for in-hospital mortality for patients with trauma and sepsis in intensive care units.

The predictive values of admission characteristics for 28-day all-cause mortality in septic patients with diabetes mellitus: a study from the MIMIC database

“…Sepsis is still the leading cause of death in patients elected to the ICU ( 15 , 18 ). In the present study, the 28-day mortality rate of septic patients with DM was 23.9% (n=533), which was higher than in general septic patients (10%-15%) ( 34 – 36 ). Regarding the hospitalization characteristics of the study population, we observed that survivors showed longer hospital and ICU stays than non-survivors, which was consistent with previous studies ( 24 , 37 ).…”

“…There is a significant increase in the prevalence of DM in the elderly population ( 48 – 50 ), leading to exacerbation, poor prognosis, and increased mortality risk in sepsis ( 51 ). Additionally, serum biomarkers were important predictors in the surveillance of critically ill patients ( 34 , 36 , 52 – 55 ). Septic patients were often accompanied by hypoproteinemia due to capillary leakage, reperfusion injury, tissue ischemia, and inflammation ( 56 , 57 ).…”

Temporal Trend and Research Focus of Injury Burden from 1998 to 2022: A Bibliometric Analysis

“…2 According to the World Health Organization (WHO) statistics, about 10% of deaths and 16% of disabled are caused by injury globally. 3 Injury is not only associated with an increased risk of adverse health outcomes (eg, venous thromboembolism, acute kidney injury, post-traumatic stress disorder, and sleep disorders) but also regularly poses a significant economic impact on patients' families and society. [4][5][6][7][8] It has been reported that the costs of injuryrelated care were estimated to exceed 400 billion dollars per year in the United States of America (USA) alone.…”