A no-carrier-added<sup>72</sup>Se/<sup>72</sup>As radionuclide generator based on solid phase extraction

Alpha particles exhibit three important characteristics: scattering, ionisation and activation. This article briefly discusses those properties and outlines their major applications. Among others, -particles are used in elemental analysis, investigation and improvement of materials properties, nuclear reaction studies and medical radionuclide production. The latter two topics, dealing with activation of target materials, are treated in some detail in this paper. Measurements of excitation functions of -particle induced reactions shed some light on their reaction mechanisms, and studies of isomeric cross sections reveal the probability of population of highspin nuclear levels. Regarding medical radionuclides, an overview is presented of the isotopes commonly produced using -particle beams. Consideration is also given to some routes which could be potentially useful for production of a few other radionuclides. The significance of -particle induced reactions to produce a few high-spin isomeric states, decaying by emission of low-energy conversion or Auger electrons, which are of interest in localised internal radiotherapy, is outlined. The -particle beam, thus broadens the scope of nuclear chemistry research related to development of non-standard positron emitters and therapeutic radionuclides.

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“…Mode of Production method using -particles [46,49,55,[164][165][166]207]). The yields are, however, much lower (cf.…”

Section: /2mentioning

confidence: 99%

Uses of alpha particles, especially in nuclear reaction studies and medical radionuclide production

et al. 2016

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“…[124][125][126][127]. The metals of interest are Fe and Ni and the potentially useful positron emitting radionuclides could be 52 Fe (T 1/2 = 8.3 h) and 57 Ni (T 1/2 = 36.0 h), respectively. In view of the increasing interest in multimode imaging, the need for further development of suitable novel positron emitters will certainly increase.…”

Section: Research Orientationsmentioning

confidence: 99%

The present and future of medical radionuclide production

Qaim

2012

Radiochimica Acta

100

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Reactor and cyclotron production of medical radionuclides / γ -ray emitters for SPECT / Positron emitters for PET / Corpuscular radiation emitters for internal radiotherapy / Low and intermediate energy nuclear reactions / Radionuclide generators / Future directionsSummary. Medical radionuclide production technology is well established. Both reactors and cyclotrons are utilized for production; the positron emitters, however, are produced exclusively using cyclotrons. A brief survey of the production methods of most commonly used diagnostic and therapeutic radionuclides is given. The emerging radionuclides are considered in more detail. They comprise novel positron emitters and therapeutic radionuclides emitting low-range electrons and α-particles. The possible alternative production routes of a few established radionuclides, like 68 Ga and 99m Tc, are discussed. The status of standardisation of production data of the commonly used as well as of some emerging radionuclides is briefly mentioned. Some notions on anticipated future trends in the production and application of radionuclides are considered.

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“…102,103]. Nonetheless two generator systems for obtaining the daughter 72 As, one based on distillation [137] and the other one on solid phase extraction [138] have been developed. With regard to 140 Nd, the ( p, 2n) and ( 3 He, xn) reactions on 141 Pr and nat Ce, respectively, have been investigated in detail [cf .…”

Section: Production Of Novel Parent Generator Radionuclidesmentioning

confidence: 99%

Development of novel positron emitters for medical applications: nuclear and radiochemical aspects

Qaim¹

2011

Ract

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In molecular imaging, the importance of novel longer lived positron emitters, also termed as non-standard or innovative PET radionuclides, has been constantly increasing, especially because they allow studies on slow metabolic processes and in some cases furnish the possibility of quantification of radiation dose in internal radiotherapy. Considerable efforts have been invested worldwide and about 25 positron emitters have been developed. Those efforts relate to interdisciplinary studies dealing with basic nuclear data, high current charged particle irradiation, efficient radiochemical separation and quality control of the desired radionuclide, and recovery of the enriched target material for reuse. In this review all those aspects are briefly discussed, with particular reference to three radionuclides, namely 64 Cu, 124 I and 86 Y, which are presently in great demand. For each radionuclide several nuclear routes were investigated but the ( p, n) reaction on an enriched target isotope was found to be the best for use at a small-sized cyclotron. Some other positron emitting radionuclides, such as 55 Co, 76 Br, 89 Zr, 82m Rb, 94m Tc, 120 I, etc., were also produced via the low-energy ( p, n), ( p, α) or (d, n) reaction. On the other hand, the production of radionuclides 52 Fe, 73 Se, 83 Sr, etc. using intermediate energy ( p, xn) or (d, xn) reactions needs special consideration, the nuclear data and chemical processing methods being of key importance. In a few special cases, a high intensity 3 He-or α-particle beam could be an added advantage. The production of some potentially interesting positron emitters via generator systems, for example 44 Ti/ 44 Sc, 72 Se/ 72 As and 140 Nd/ 140 Pr is considered. The significance of new generation high power accelerators is briefly discussed.

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A no-carrier-added⁷²Se/⁷²As radionuclide generator based on solid phase extraction

Cited by 42 publications

References 14 publications

Uses of alpha particles, especially in nuclear reaction studies and medical radionuclide production

Uses of alpha particles, especially in nuclear reaction studies and medical radionuclide production

The present and future of medical radionuclide production

Development of novel positron emitters for medical applications: nuclear and radiochemical aspects

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A no-carrier-added72Se/72As radionuclide generator based on solid phase extraction

Cited by 42 publications

References 14 publications

Uses of alpha particles, especially in nuclear reaction studies and medical radionuclide production

Uses of alpha particles, especially in nuclear reaction studies and medical radionuclide production

The present and future of medical radionuclide production

Development of novel positron emitters for medical applications: nuclear and radiochemical aspects

Contact Info

Product

Resources

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A no-carrier-added⁷²Se/⁷²As radionuclide generator based on solid phase extraction