A NIR ratiometric fluorescent probe for the rapid detection of hydrogen sulfide in living cells and zebrafish

Qin, Xue; Liu, Xingyue; Wang, Jing; Chen, Hua; Shen, Xing‐Can

doi:10.1016/j.talanta.2023.125043

Cited by 14 publications

(5 citation statements)

References 56 publications

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“…Compared with other traditional detection techniques such as atomic absorption spectroscopy, atomic emission spectroscopy and mass spectrometry, fluorescence probes have the advantages of high sensitivity, good selectivity, simple operation, in situ detection, minimal damage to organisms and visualization. As a new efficient and convenient detection method, fluorescent probes play a very important role in the detection of metal ions, phosphate anions and small biological molecules [97][98][99][100].…”

Section: Fluorescent Probesmentioning

confidence: 99%

Advances in the synthesis and applications of macrocyclic polyamines

Gao,

Guo,

Liu

et al. 2024

R. Soc. Open Sci.

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Macrocyclic polyamines constitute a significant class of macrocyclic compounds that play a pivotal role in the realm of supramolecular chemistry. They find extensive applications across diverse domains including industrial and agricultural production, clinical diagnostics, environmental protection and other multidisciplinary fields. Macrocyclic polyamines possess a distinctive cavity structure with varying sizes, depths, electron-richness degrees and flexibilities. This unique feature enables them to form specific supramolecular structures through complexation with diverse objects, thereby attracting considerable attention from chemists, biologists and materials scientists alike. However, there is currently a lack of comprehensive summaries on the synthesis methods for macrocyclic polyamines. In this review article, we provide an in-depth introduction to the synthesis of macrocyclic polyamines while analysing their respective advantages and disadvantages. Furthermore, we also present an overview of the recent 5-year advancements in using macrocyclic polyamines as non-viral gene vectors, fluorescent probes, diagnostic and therapeutic reagents as well as catalysts. Looking ahead to future research directions on the synthesis and application of macrocyclic polyamines across various fields will hopefully inspire new ideas for their synthesis and use.

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Section: Fluorescent Probesmentioning

confidence: 99%

Advances in the synthesis and applications of macrocyclic polyamines

Gao,

Guo,

Liu

et al. 2024

R. Soc. Open Sci.

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“…S1: Comparison of HND for the detection of H2S. References [43][44][45] are cited in Supplementary Materials.…”

Section: Supplementary Materialsmentioning

confidence: 99%

“…mdpi.com/article/10.3390/molecules29102386/s1, Figure S1: 1 H-NMR of HND. S1: Comparison of HND for the detection of H 2 S. References [43][44][45] are cited in Supplementary Materials.…”

Section: Supplementary Materialsmentioning

confidence: 99%

An Aggregation-Induced Fluorescence Probe for Detection H2S and Its Application in Cell Imaging

Tang,

Zhang,

Wang

et al. 2024

Molecules

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Monitoring hydrogen sulfide (H2S) in living organisms is very important because H2S acts as a regulator in many physiological and pathological processes. Upregulation of endogenous H2S concentration has been shown to be closely related to the occurrence and development of tumors, atherosclerosis, neurodegenerative diseases and diabetes. Herin, a novel fluorescent probe HND with aggregation-induced emission was designed. Impressively, HND exhibited a high selectivity, fast response (1 min) and low detection limit (0.61 μM) for H2S in PBS buffer (10 mM, pH = 7.42). Moreover, the reaction mechanism between HND and H2S was conducted by Job’s plot, HR-MS, and DFT. In particular, HND was successfully employed to detect H2S in HeLa cells.

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“…Among various detection strategies, fluorescent probes have emerged as powerful tools for detection due to their high sensitivity, real-time monitoring capabilities, and ability to provide spatiotemporal imaging and are widely used in fields such as food inspection, environmental monitoring, and biological imaging. − In recent years, a number of small molecule fluorescent probes have been successfully developed for H 2 S detection (Table S1). However, some of these probes exhibit noticeable drawbacks, including tedious synthesis steps, non-near-infrared emission (<650 nm), small Stokes shift (<100 nm), poor biocompatibility (test solution system has a high proportion of organic solvents), potential biotoxicity, and susceptibility to interference from other analytes (particularly biothiols) .…”

Section: Introductionmentioning

confidence: 99%

A Near-Infrared Fluorescent Probe with Large Stokes Shift for Sensitive Detection of Hydrogen Sulfide in Environmental Water, Food Spoilage, and Biological Systems

Chen,

Bao,

Pan

et al. 2024

J. Phys. Chem. B

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Hydrogen sulfide (H 2 S) is an important endogenous gas transmitter that plays a critical role in various physiological and pathological processes and can also cause a negative impact on foodstuffs. In this study, we designed and synthesized a simple, easily available, highyield, and low-cost near-infrared (λ em = 710 nm) fluorescent probe, DEM-H 2 S, with a substantial Stokes shift (205 nm) for the detection of H 2 S. DEM-H 2 S features high selectivity and sensitivity (LOD = 80 nM) toward H 2 S, accompanied by a noticeable color change. Upon interaction with H 2 S, DEM-H 2 S exhibits a restored ICT (Intramolecular Charge Transfer) process, thereby manifesting near-infrared fluorescence. DEM-H 2 S has been successfully utilized to detect H 2 S in actual water samples and to monitor the spoilage of food items, such as pork, shrimp, and eggs. Furthermore, DEM-H 2 S enables the imaging of endogenous and exogenous H 2 S in living MCF-7 cells and zebrafish. Hence, DEM-H 2 S provides an attractive method for the detection of H 2 S in environmental, food, and biological systems, holding potential value in physiological and pathological research.

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A NIR ratiometric fluorescent probe for the rapid detection of hydrogen sulfide in living cells and zebrafish

Cited by 14 publications

References 56 publications

Advances in the synthesis and applications of macrocyclic polyamines

Advances in the synthesis and applications of macrocyclic polyamines

An Aggregation-Induced Fluorescence Probe for Detection H2S and Its Application in Cell Imaging

A Near-Infrared Fluorescent Probe with Large Stokes Shift for Sensitive Detection of Hydrogen Sulfide in Environmental Water, Food Spoilage, and Biological Systems

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