A NIR fluorescent probe for the specific detection of hypochlorite and its application in vitro and in vivo

Abstract

A colorimetric NIR fluorescent probe for detecting ClO− has been synthesized. And it had outstanding advantages: one-step synthesis, high sensitivity , selectivity and successful application in actual water samples, living cells and zebrafish.

A ratiometric near‐infrared fluorescent probe for the detection and monitoring of hypochlorous acid in rheumatoid arthritis model and real water samples

“…Before performing imaging of HOCl in vivo, the cytotoxicity of PTA was preferentially tested using a standard MTT assay [46] . After incubating the A549 cells with PTA (10 and 20 μM) for 24 h, the viability of A549 cells was maintained at a high level (94.67% and 90.82%), respectively (Figure ).…”

Borylation of phenols using sulfuryl fluoride activation

“…[6][7][8] Moreover, fluorescent sensors containing the boronic ester group are emerging as important compounds in the detection and quantitation of reactive oxygen species in the cells of organisms. [9][10][11] To prepare arylboronic esters, the transition-metal-catalyzed Miyaura borylation of aryl halides constitutes a common and practical approach. [12][13][14][15][16] Over the past decade, the direct borylation of less reactive C-H, [17][18][19][20][21] C-F, 22,23 C-S, 24,25 C-N, 26,27 and C-C [28][29][30][31][32] bonds has also been developed to enrich the preparation methods of boronic esters.…”

Selective detection of peroxynitrite using an isatin receptor and a naphthalimide fluorophore

“…19 However, these receptors can also react with other ROS species, such as hydrogen peroxide and hypochlorite. [20][21][22][23][24] Significantly, isatin exhibits a sensitive, selective and rapid response to peroxynitrite. [25][26][27][28] Naphthalimide fluorophores are on the whole cell permeable and exhibit good photostabilities.…”

“…19 However, these receptors can also react with other ROS species, such as hydrogen peroxide and hypochlorite. 20–24 Significantly, isatin exhibits a sensitive, selective and rapid response to peroxynitrite. 25–28…”