A Nicotine-Focused Framework for Public Health

Gottlieb, Scott; Zeller, Mitch

doi:10.1056/nejmp1707409

Cited by 267 publications

(243 citation statements)

References 3 publications

Supporting

Mentioning

236

Contrasting

Unclassified

Order By: Relevance

“…Recently the FDA announced its intention to pursue such a policy (Gottlieb and Zeller, 2017). Reducing levels of nicotine to below the threshold that can maintain addiction has the potential to impact the pattern of cigarette smoking over the lifetime (Benowitz and Henningfield, 2013).…”

Section: Introductionmentioning

confidence: 99%

Adolescent smokers’ response to reducing the nicotine content of cigarettes: Acute effects on withdrawal symptoms and subjective evaluations

Cassidy

Colby

Tidey

et al. 2018

Drug and Alcohol Dependence

View full text Add to dashboard Cite

Background: Mandating a reduction in the nicotine content of cigarettes to a minimally addictive level could dramatically reduce smoking rates in the US. However, little is known about the effects of reduced nicotine content cigarettes in adolescents. Methods: Following overnight abstinence, adolescent daily smokers (ages 15–19, n = 50) reported on their craving, withdrawal, and positive and negative affect pre- and post- ad lib smoking of one cigarette containing varying nicotine content (15.8, 5.2, 1.3 and 0.4 mg/g of tobacco) in the laboratory and reported their subjective evaluations of each cigarette. Carbon monoxide (CO) boost from pre- to post-cigarette was calculated to determine if lower-nicotine cigarettes led to differential acute changes in toxicant exposure. Results: All four nicotine cigarette types significantly reduced abstinence-induced craving, withdrawal, and negative affect (all p’s<.05). Mixed models evaluating the effect of nicotine content, with nicotine dependence level and gender included as covariates, revealed a significant effect of nicotine content on craving and subjective evaluations: higher nicotine content resulted in greater reductions in craving and increases in both positive and negative subjective evaluations. There were no significant effects of nicotine dose on withdrawal symptoms, negative affect, or CO boost. Conclusions: These results suggest that lower nicotine cigarettes might result in reduced abuse liability compared to higher nicotine content cigarettes due to reduced positive subjective effects, while still reducing withdrawal, in adolescents. These results highlight the potential feasibility of this policy approach and support continued research on how a nicotine reduction policy may affect adolescent smoking patterns.

show abstract

Section: Introductionmentioning

confidence: 99%

Adolescent smokers’ response to reducing the nicotine content of cigarettes: Acute effects on withdrawal symptoms and subjective evaluations

Cassidy

Colby

Tidey

et al. 2018

Drug and Alcohol Dependence

View full text Add to dashboard Cite

show abstract

“…The Food and Drug Administration (FDA) recently announced a new tobacco control framework that includes a nicotine reduction policy for cigarettes 1. By mandating that all cigarettes sold in the USA have minimally addictive nicotine levels,2 fewer adolescents may transition to becoming adult smokers and current smokers may be more successful at quitting 3.…”

Section: Introductionmentioning

confidence: 99%

Correlates of support for a nicotine-reduction policy in smokers with 6-week exposure to very low nicotine cigarettes

et al. 2018

View full text Add to dashboard Cite

BackgroundThe US Food and Drug Administration recently issued an advanced notice of proposed rule-making for reducing the nicotine content in cigarettes to a minimally addictive level. Very little is known about whether use of very low nicotine content (VLNC) cigarettes affects support for a nicotine reduction policy.ObjectiveThis study examined the effects of using VLNC versus usual brand (UB) cigarettes on support for a nicotine reduction policy and determined whether participant characteristics and responses to VLNC cigarettes were associated with policy support.MethodsParticipants from a cigarette trial who were assigned to either 0.4 mg nicotine/g tobacco research cigarettes or their UB for 6 weeks were asked about their support for the policy. χ2 tests were used to compare support for the policy between cigarette conditions and logistic regression analyses were conducted to assess covariates associated with policy support.FindingsPolicy support did not differ by condition. After 6 weeks of using VLNC cigarettes, 50% of participants supported the policy, 26% opposed and 24% responded ‘Don’t Know’. Support was higher among those adherent to smoking only VLNC cigarettes (65%) compared with those who were non-adherent (44%). Older participants and those interested in quitting had increased odds of support. Cigarette satisfaction, perceived harm and perceived nicotine content were not significantly associated with support.ConclusionsSmoking VLNC cigarettes did not affect support for a nicotine reduction policy. Understanding predictors of policy support and opposition will help public health officials to maximise the public health acceptance and impact of this policy (ClinicalTrials.gov Identifier: NCT01681875 Post-Results).

show abstract

“…ACS CAN will: Advocate for and defend against attacks on the full implementation of the FDA's authority over the manufacture, marketing, and distribution of tobacco products granted by the Family Smoking Prevention and Tobacco Control Act; and Advocate that the FDA's new comprehensive plan should leverage the collective authorities of its different centers to work collaboratively toward the goal of decreasing the number of people who use and are harmed by tobacco …”

Section: Accelerate Efforts To End Combustible Tobacco Use: Key Stratmentioning

confidence: 99%

“…Advocate for and defend against attacks on the full implementation of the FDA's authority over the manufacture, marketing, and distribution of tobacco products granted by the Family Smoking Prevention and Tobacco Control Act; and Advocate that the FDA's new comprehensive plan should leverage the collective authorities of its different centers to work collaboratively toward the goal of decreasing the number of people who use and are harmed by tobacco. 39 Conclusions "The American Cancer Society's mission is to save lives, celebrate lives, and lead the fight for a world without cancer." 40 It is in the spirit of that inspirational message that this Public Health Statement is framed.…”

Section: Acs Can Willmentioning

confidence: 99%

The American Cancer Society public health statement on eliminating combustible tobacco use in the United States

Douglas

Henson

Drope

et al. 2018

CA A Cancer J Clinicians

View full text Add to dashboard Cite

A Nicotine-Focused Framework for Public Health

Cited by 267 publications

References 3 publications

Adolescent smokers’ response to reducing the nicotine content of cigarettes: Acute effects on withdrawal symptoms and subjective evaluations

Adolescent smokers’ response to reducing the nicotine content of cigarettes: Acute effects on withdrawal symptoms and subjective evaluations

Correlates of support for a nicotine-reduction policy in smokers with 6-week exposure to very low nicotine cigarettes

The American Cancer Society public health statement on eliminating combustible tobacco use in the United States

Contact Info

Product

Resources

About