A newly validated HPLC–DAD-UV method to study the effects of medicinal plants extracts, fractions and isolate compounds on gastric emptying in rodents

Siqueira, Monica Regina Pimentel; Rosa, Lorenna C. da; Santos, Rafael dos; Lopes, Marina Priscila G. da S.; Paumgartten, Francisco José Roma; Moreira, Davyson de Lima

doi:10.1016/j.bjp.2019.03.003

Cited by 2 publications

(1 citation statement)

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“…In the 70s, it was evidenced in studies carried out on the leaves, that M. ilicifolia had triterpenoid compounds in its composition, which were verified to have cytotoxic action against tumour cells in vitro research [9]. During the 1980s, studies were stimulated by their effectiveness in treating gastric ulcers, gastritis, dyspepsia and indigestion, properties that were later confirmed in the late 1980s [10] and more recently [11].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Compounds in the Plant Maytenus ilicifolia Mart. Ex Reissek during the Initial and Adult Development Stage

Alvarenga

Coelho

Sakai

et al. 2020

EJMP

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Maytenus ilicifolia Mart. Ex Reissek, was first studied in the 60s, but only in the 80s and 90s were the studies were driven by scientific research that attributed medicinal properties to the plant, such as healing actions for human gastric diseases. In this work, a study was carried out on the characterization of the chemical composition of M. ilicifolia at different stages of development, using spectroscopic techniques of sustainable character, which do not require toxic solvents as previous preparations. Extracts from cotyledons, seedlings that have never been researched in the literature and leaf/stem were lyophilized to characterize the compounds present in this plant using photoacoustic and spectroscopy techniques in the Infrared spectroscopy using Fourier Transform-FTIR with ATR. The photoacoustic results show that there is a differentiation of development stages in the plant due to the greater presence of chlorophylls and terpenes in the seedlings and their absence in the cotyledon, which is characterized as the reserve part in the germination phase of the plant. The range of bands the literature reports for epigallocatechin and friedelin, the possible agents responsible for the medicinal effects of the plant were mainly seen in the cotyledon, thus demonstrating the use of the seedling in its initial stage, to extract and obtain these active components.

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Section: Introductionmentioning

confidence: 99%