A Newly Recognized Blood Group in Domestic Shorthair Cats: The Mik Red Cell Antigen

Weinstein, Nicole; Blais, Marie‐Claude; Harris, Kimberly; Oakley, Donna A.; Aronson, Lillian R.; Giger, Urs

doi:10.1892/0891-6640(2007)21[287:anrbgi]2.0.co;2

Cited by 81 publications

(147 citation statements)

References 25 publications

Supporting

Mentioning

135

Contrasting

Unclassified

Order By: Relevance

“…Recognition of the feline RBC antigen Mik and naturally occurring anti‐ Mik alloantibodies in 2007 prompted the recommendation to consider performing a crossmatch before a cat's first RBC transfusion 12. With 3 of 65 blood donor cats having naturally occurring anti‐ Mik alloantibodies,12 the prevalence of naturally occurring, non‐AB RBC alloantibodies would be expected to be at least 5%, not taking into account the possibility of alloantibodies to RBC antigens other than Mik .…”

Section: Discussionmentioning

confidence: 99%

“…Crossmatch (major, minor, and auto control to evaluate for RBC agglutination) was performed using a standard tube method, as previously described,12 by experienced technical staff of our institution's clinical laboratory or, after hours, by emergency service personnel or the primary clinician on the case. The following scale was used: 4+, single large agglutinate of RBCs; 3+, few large agglutinates of RBCs; 2+, large agglutinates of RBCs amid many smaller RBC clumps; 1+, many small RBC agglutinates amid a background of free cells; and negative, no granularity 12. Hemolysis was also recorded if noted.…”

Section: Methodsmentioning

confidence: 99%

“…In 2007, a new feline RBC antigen, Mik , was recognized after a type A‐matched RBC transfusion resulted in an acute hemolytic transfusion reaction in a Mik ‐negative cat with anti‐ Mik alloantibodies that received blood from a Mik ‐positive donor 12. Anti‐ Mik alloantibodies are naturally occurring but could develop after an RBC transfusion in a Mik ‐negative cat 12…”

Section: Introductionmentioning

confidence: 99%

“…Anti‐ Mik alloantibodies are naturally occurring but could develop after an RBC transfusion in a Mik ‐negative cat 1212. Although the standard recommendation has been to perform a crossmatch for cats (and dogs) that are to receive blood >4 days after their first transfusion,11, 12 documentation of naturally occurring anti‐ Mik alloantibodies and the possibility of other non‐AB, non‐ Mik alloantibodies in cats has prompted the recommendation to consider a crossmatch for cats before their first RBC transfusion 12.…”

Section: Introductionmentioning

confidence: 99%

“…Mik appears to be a common RBC antigen, with few Mik ‐negative cats identified thus far; however, typing for the Mik antigen is restricted because of a lack of typing reagent (ie, serum from a Mik ‐negative cat having anti‐ Mik alloantibodies) 12. Although the standard recommendation has been to perform a crossmatch for cats (and dogs) that are to receive blood >4 days after their first transfusion,11, 12 documentation of naturally occurring anti‐ Mik alloantibodies and the possibility of other non‐AB, non‐ Mik alloantibodies in cats has prompted the recommendation to consider a crossmatch for cats before their first RBC transfusion 12. Furthermore, administration of type‐specific, crossmatch‐compatible pRBCs to cats has been associated with a significantly greater increase in PCV posttransfusion compared to cats receiving typed, non‐crossmatched pRBCs 13…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Prevalence of naturally occurring non‐AB blood type incompatibilities in cats and influence of crossmatch on transfusion outcomes

McClosky

Brown

Weinstein

et al. 2018

Veterinary Internal Medicne

Self Cite

View full text Add to dashboard Cite

BackgroundRecognition of the feline red blood cell (RBC) antigen Mik and the presence of naturally occurring anti‐Mik antibodies resulting in acute hemolytic transfusion reactions prompted the recommendation to perform a crossmatch before a cat's first RBC transfusion, but this guideline has not yet become a standard practice.ObjectiveTo determine the prevalence of naturally occurring non‐AB alloantibodies detectable by tube crossmatch, and to compare transfusion outcomes in cats with and without a crossmatch performed.AnimalsThree hundred cats that received an RBC transfusion, with or without a major crossmatch performed.MethodsRetrospective study.ResultsMajor crossmatch incompatibilities were documented in 23 of 154 transfusion‐naive cats (14.9%) and in 15 of 55 previously transfused cats (27%; P = 0.042). Type‐specific packed RBCs (pRBCs) were administered to 167 and 82 cats with and without a crossmatch, respectively. Median volume of pRBCs administered during the first transfusion was 5.3 mL/kg (range, 2.4‐18 mL/kg). Median change in PCV scaled to dose of pRBCs was +0.8%/mL/kg; administration of crossmatch‐compatible pRBCs was not associated with a greater increase in PCV. Febrile transfusion reactions occurred more often in cats that received non‐crossmatched (10.1%) compared to crossmatched (2.5%) pRBCs (P = 0.022). Seventy‐six percent of cats that received pRBC transfusions survived to hospital discharge. A crossmatch was not associated with improved survival to discharge or at 30 or 60 days posttransfusion.Conclusions and Clinical ImportanceThe prevalence of naturally occurring non‐AB incompatibilities is sufficiently high to justify the recommendation to perform a crossmatch before all (including the first) RBC transfusions in cats.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%