A Newly Discovered Variant of a Hantavirus in<i>Apodemus peninsulae</i>, Far Eastern Russia

Yashina, L. N.; Mishin, Vasiliy P.; Zdanovskaya, Nina I.; Schmaljohn, Connie S.; Иванов, Л. И.

doi:10.3201/eid0705.017530

Cited by 25 publications

(12 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We detected antibodies to hantaviruses in A. peninsulae , and the viral genome characteristics were extremely similar to the newly identified genotype, AMR (10). Using phylogenetic analysis to characterize the sequences of viruses identified from HFRS patients and A. peninsulae , we were able to corroborate the assumption of Yashina et al (11). We also found that A. peninsulae -related viruses are pathogenic for humans and are distributed over a large area of east Asia that includes Far East Russia.…”

supporting

confidence: 79%

See 1 more Smart Citation

Genetic Characterization of Hantaviruses Transmitted by the Korean Field Mouse (Apodemus peninsulae), Far East Russia

Lokugamage

Kariwa

Hayasaka

et al. 2002

Emerg. Infect. Dis.

View full text Add to dashboard Cite

In an epizootiologic survey of 122 rodents captured in Vladivostok, Russia, antibodies positive for hantavirus were found in Apodemus peninsulae (4/70), A. agrarius (1/39), and Clethrionomys rufocanus (1/8). The hantavirus sequences identified in two seropositive A. peninsulae and two patients with hemorrhagic fever with renal syndrome (HFRS) from the Primorye region of Far East Russia were designated as Solovey and Primorye, respectively. The nucleotide sequences of the Solovey, Primorye, and Amur (obtained through GenBank) sequences were closely related (>92% identity). Solovey and Primorye sequences shared 84% nucleotide identity with the prototype Hantaan 76-118. Phylogenetic analysis also indicated a close relationship between Solovey, Primorye, Amur, and other viruses identified in Russia, China, and Korea. Our findings suggest that the Korean field mouse ( A. peninsulae ) is the reservoir for a hantavirus that causes HFRS over a vast area of east Asia, including Far East Russia.

show abstract

supporting

confidence: 79%

“…The natural reservoir of AMR genotype seems to be A. peninsulae , according to a recent study on nucleotide sequence comparisons by Yashina et al (11).…”

mentioning

confidence: 99%

Genetic Characterization of Hantaviruses Transmitted by the Korean Field Mouse (Apodemus peninsulae), Far East Russia

Lokugamage

Kariwa

Hayasaka

et al. 2002

Emerg. Infect. Dis.

View full text Add to dashboard Cite

show abstract

“…The few human HFRS cases in Africa [113] and America [115] were not demonstrated to be associated with SEOV, and no clear evidence of SEOV-related HFRS is available in Europe except from laboratory infections [116]. Amur and Far East viruses were recently identified in severe HFRS cases in the far eastern region of the Russia Federation [117,118], and need to be further characterized.…”

Section: Hantaviruses Causing Human Infections Hfrs-associated Hantavmentioning

confidence: 99%

Hantavirus Infection: a review and global update

Formenty

Roth

2008

J Infect Dev Ctries

200

215

View full text Add to dashboard Cite

Hantaviruses have the potential to cause two different types of diseases in human: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). HFRS, initially described clinically at the turn of the 20 th century, occurs endemically in the Asian and European continents, while HPS, recognized as a clinical entity since 1993, represents the prototype of emerging diseases occurring in the Western hemisphere. Approximately 150,000 to 200,000 cases of HFRS are hospitalized each year world wide, with most of the cases occurring in the developing countries. The case fatality rate of HFRS varies from <1% to 12% depending on the viruses. Although HPS is much smaller in number than HFRS, with approximately 200 HPS cases per year in the Americas, the average case fatality rate is 40%. The reported cases of hantaviral infection is increasing in many countries and new hantavirus strains have been increasingly identified worldwide, which constitutes a public health problem of increasing global concern. Hantaviral infection might be underestimated due to its asymptomatic and nonspecific mild infection, and the lack of simple standardized laboratory diagnostics in hospitals, especially in the developing countries. This review summarizes the current knowledge on virology, epidemiology, clinical manifestation, laboratory diagnostics, treatment and prevention of hantaviruses and hantaviral infections.

show abstract

“…SOO virus sequences from four Vero E6 cell-culture isolates were aligned and compared with previously published hantavirus sequences [Liang et al, 1994;Baek et al, 1998;Yashina et al, 2000Yashina et al, , 2001, using the Clustal W method (Lasergene program version 5, DNASTAR, Inc., Madison, WI). The GenBank accession numbers for the S segment of SOO virus strains SOO-1, SOO-2, SOO-3, and SOO-4 were AY675349, AY675350, AY675351, and AY675352; for the M segment of strains SOO-1, SOO-2, and SOO-3, they were AY675353, DQ056293, and DQ056295; and for the L segment of strains SOO-1 and SOO-2, they were DQ056292 and AY675354, respectively.…”

Section: Phylogenetic Analysismentioning

confidence: 99%

Soochong virus: An antigenically and genetically distinct hantavirus isolated fromApodemus peninsulae in Korea

et al. 2005

View full text Add to dashboard Cite

Hantaan (HTN) virus, the etiologic agent of clinically severe hemorrhagic fever with renal syndrome (HFRS), was first isolated in 1976 from lung tissue of a striped-field mouse (Apodemus agrarius) captured in Songnae-ri, Gyeonggi Province, Republic of Korea. Found primarily in mountainous areas, the Korean field mouse (A. peninsulae) is the second-most dominant field rodent species found throughout Korea. A new hantavirus, designated Soochong (SOO), was isolated in Vero E6 cells from four A. peninsulae captured in August 1997 at Mt. Gyebang in Hongcheon-gun, Mt. Gachil, Inje-gun, Gangwon Province, and in September 1998 at Mt. Deogyu, Muju-gun, Jeollabuk Province. The entire S, M, and L genomic segments of SOO virus, amplified by RT-PCR from lung tissues of seropositive A. peninsulae and from virus-infected Vero E6 cells, diverged from HTN virus (strain 76-118) by 15.6%, 22.8%, and 21.7% at the nucleotide level and 3.5%, 9.5%, and 4.6% at the amino acid level, respectively. Phylogenetic analyses of the nucleotide and deduced amino acid sequences, using the maximum parsimony and neighbor-joining methods, indicated that SOO virus was distinct from A. agrarius-borne HTN virus. SOO virus shared a common ancestry with Amur virus from Far East Russia, as well as with H5 and B78 hantaviruses, previously isolated from HFRS patients in China. Cross-focus-reduction neutralizating antibody tests showed that SOO virus, which is the first hantavirus isolated in cell culture from A. peninsulae, could be classified as a new hantavirus serotype.

show abstract

A Newly Discovered Variant of a Hantavirus inApodemus peninsulae, Far Eastern Russia

Cited by 25 publications

References 5 publications

Genetic Characterization of Hantaviruses Transmitted by the Korean Field Mouse (Apodemus peninsulae), Far East Russia

Genetic Characterization of Hantaviruses Transmitted by the Korean Field Mouse (Apodemus peninsulae), Far East Russia

Hantavirus Infection: a review and global update

Soochong virus: An antigenically and genetically distinct hantavirus isolated fromApodemus peninsulae in Korea

Contact Info

Product

Resources

About