A newborn with cyanosis

The origin of hydrogen sulfide in a newborn with sulfhaemoglobin induced cyanosis

“…I n a previous paper we presented a 3 day old boy with a sulfhaemoglobin induced cyanosis, with emphasis on the clinical aspects of the case. 1 Sulfhaemoglobin is a green pigmented haemoglobin with a H 2 S derived sulfur on the haem iron. 2 In this paper we focus on the production and on the origin of H 2 S. Therefore, we collected and studied frozen material from this newborn boy after death.…”

Neonatal Sulfhemoglobinemia and Hemolytic Anemia Associated With Intestinal Morganella morganii

“…25 We could not find any previous reports of M morganii being associated with sulfhemoglobinemia, but there has been a recent case study of SHb induced cyanosis in a neonate involving a hemolytic Escherichia coli. 26,27 Unlike our subject, the previous patient did not survive and died of multiple organ failure with an additional underlying diagnosis of meconium ileus due to cystic fibrosis. In addition, E coli and hemolysis were detected in nearly all organs, strongly suggesting an extraintestinal role of the E coli hemolysin.…”

Food for Thought

“…On the second day after admission (the 5th day of life) the boy died from severe septic shock and multiple organ failure. 1 Necropsy showed extensive haemorrhages in nearly all organs and interstitia. Cytogenetic analysis of the patient's tissue was consistent with the diagnosis of cystic fibrosis (mutation δF508).…”

“…1 Sulfhaemoglobin is a green pigmented haemoglobin with a H 2 S derived sulfur on the haem iron. 2 In this paper we focus on the production and on the origin of H 2 S. Therefore, we collected and studied frozen material from this newborn boy after death.…”