A New Way to Silicone‐Based Peptide Polymers

Abstract

We describe a new class of silicone-containing peptide polymers obtained by a straightforward polymerization in water using tailored chlorodimethylsilyl peptide blocks as monomeric units. This general strategy is applicable to any type of peptide sequences, yielding linear or branched polymer chains composed of well-defined peptide sequences.

Sol-gel and peptides: an attractive route to unprecedented biomaterials

“…We already used this sol-gel process to prepare peptide-functionalized fluorescent silica nanoparticles [10,11], grafting of wound-healing or antibacterial peptides on silicone catheter, [12] dressings [13] and titanium [14] and comb-like and silicone linear polymers were prepared. [15,16] At pH 7, the sol gel process needs to be catalyzed with a nucleophilic compound to faster the gelation. We selected sodium fluoride at low and non-toxic concentration (< 0.3 mg/ml) to perform the hydrolysis of alkoxysilane and subsequent condensation reactions (Fig.…”

Selective homodimerization of unprotected peptides using hybrid hydroxydimethylsilane derivatives

“…This result was in agreement with what we already observed on siloxane polymers. 12 In the presence of water, dimer 1 was hydrolyzed. To study the inuence of pH on the dimer hydrolysis rate, dimer 1a was dissolved at 0.1 M in D 2 O at pH 4, 7, 7.4 and 10.…”

“…We recently applied this strategy to the synthesis of linear and branched peptide-polymers and tripeptide dimers. 12 In this work, we aimed at demonstrating that the strategy is not only applicable to the synthesis of N-ter dimers but also to C-ter and internal bioactive peptide sequence dimerization. Interestingly we proved here that siloxane formation simply occurred during lyophilization aer preparative RP-HPLC of the hybrid monomer.…”

Direct Synthesis of Peptide‐Containing Silicones: A New Way to Bioactive Materials

“…In contrast, direct strategies can be envisioned to obtain peptide‐containing silicone. We have already reported on the polymerization of peptides using silane chemistry to get linear and comblike peptide–polymers assembled through Si−O−Si bonds without any dichlorodimethylsilane (DCDMS) copolymerization (Figure ) . However, these hybrid peptide polymers are limited by their modest degrees of polymerization (DP<30) despite the similarities in their backbone, and they did not show comparable physicochemical properties to PDMS.…”