A new way to look at liver cancer

Locker, Joseph

doi:10.1002/hep.20368

Cited by 9 publications

(3 citation statements)

References 17 publications

(14 reference statements)

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“…[35][36][37] Possibly these criteria can be extended in the future, depending on more experience based on the stage of the disease, macrovascular invasion, histopathological characteristics (histopathology, aneuploidy, microvascular invasion) as well as DNA and RNA chip data (molecular signature, proteomic signature, and others). 38,39 Clinically, it is most important to shorten the waiting time for transplantation to !6 months. This is difficult to achieve with cadaveric liver transplantation given the shortage of donors.…”

Section: Liver Transplantationmentioning

confidence: 99%

Treatment of hepatocellular carcinoma

Blum

2005

Best Practice & Research Clinical Gastroenterology

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Section: Liver Transplantationmentioning

confidence: 99%

Treatment of hepatocellular carcinoma

Blum

2005

Best Practice & Research Clinical Gastroenterology

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“…For example, Lee et al [2] has recently reported the classification and the prediction of survival in HCC by gene expression profiling, which is ''a new way to look at liver cancer'' [3].…”

Section: Prospects For the Early 21st Centurymentioning

confidence: 99%

Hepatocellular carcinoma surgery-review of the past and prospects for the 21st century

Tang

2005

J. Surg. Oncol.

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“…Hepatocellular carcinoma (HCC) is a malignancy with high incidence, early metastasis, poor prognosis, and lack of effective treatment [ 1 – 4 ]. Chemotherapy and radiotherapy treatment efficacies are unsatisfactory, and therefore biological treatments are receiving more and more attention.…”

Section: Introductionmentioning

confidence: 99%

Basic research Suppression of human hepatocellular cancer cell proliferation by Brucea javanica oil-loaded liposomes via induction of apoptosis

Yuan¹,

Yang²,

Shi³

et al. 2015

aoms

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IntroductionHepatocellular carcinoma (HCC) is a type of malignancy with high incidence and poor prognosis. Brucea javanica is extracted from Simaroubaceae plants. It is found to have low toxicity but high anti-cancer efficiency. The aim of this study is to determine the effects of Brucea javanica oil-loaded liposomes (BJOL) on human hepatocellular cancer cell line HepG2. The related molecular mechanisms were determined.Material and methodsMorphologic changes of HepG2 cells were observed by transmission electron microscope after treatment with BJOL in vitro. Cell proliferation was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay after cell treatment with different doses of BJOL. Flow cytometry was performed. Nude mice were divided into 4 groups randomly and treated with different doses of BJOL. The apoptosis hepatocellular carcinoma was detected by TUNEL.ResultsProliferation of HepG2 was inhibited significantly by BJOL in a dose-dependent manner (2.5 mg/l or 5 mg/l). Compared with the animal models treated with the negative control, the animal models in the BJOL group had higher weight and lower metastasis rates (p < 0.01). The rate of apoptosis in hepatocellular carcinoma tissue of the BJOL groups was increased when compared with the control group (p < 0.05).ConclusionsBrucea javanica oil-loaded liposomes inhibits proliferation of HepG2. The effect appears to be dose-dependent, possibly by inducing apoptosis of cancer cells.

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A new way to look at liver cancer

Cited by 9 publications

References 17 publications

Treatment of hepatocellular carcinoma

Treatment of hepatocellular carcinoma

Hepatocellular carcinoma surgery-review of the past and prospects for the 21st century

Basic research Suppression of human hepatocellular cancer cell proliferation by Brucea javanica oil-loaded liposomes via induction of apoptosis

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