A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer
EunJung Lee,
Suyakarn Archasappawat,
Keely Ji
et al.
Abstract:Pancreatic cancer is one of the deadliest diseases in human malignancies. Among total pancreatic cancer patients, ~10% of patients are categorized as familial pancreatic cancer (FPC) patients, carrying germline mutations of the genes involved in DNA repair pathways (e.g., BRCA2). Personalized medicine approaches tailored toward patients' mutations would improve patients' outcome. To identify novel vulnerabilities of BRCA2-deficient pancreatic cancer, we generated isogenic Brca2-deficient murine pancreatic canc… Show more
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