Volatile
oils exhibit numerous biological activities including
antimicrobial, wound-healing, and antioxidant. The domestic and medical
use of these oils is, however, limited by their volatility, hydrophobic
nature, and susceptibility to degradation reactions in the presence
of air, light, and moisture. Here, we describe a three-dimensional
(3D) structured organogel system composed of a polymeric matrix (organogelator)
and three volatile oilslinalool, citral, or Mentha arvensis oilserving as the organic
phase. Increasing organogelator concentrations led to an increase
in both the storage moduli and the loss moduli attributable to a higher
degree of interaction between adjacent polymeric chains. Volatile
oils were released into the head compartment in a controlled manner,
reaching a plateau within 2 h. The antifungal activity of the various
organogels against the common dermatophyte Theridion
rubrum was evaluated in vitro. While
organogels of all sizes showed complete inhibition for citral, a dose-dependent
effect was observed for linalool and mentha oil, with the largest
disks displaying clear antifungal activity and the smallest ones displaying
negligible activity. In a follow-up experiment on an onychomycosis
model using infected horse hooves, organogels exhibited marked antifungal
activity. The ability of this system to extend the shelf life of fresh
food products was also demonstrated. The versatility of the gel, the
simplicity of its production, and its effectiveness make this system
very attractive as a delivery platform for volatile oils.