A new vegetable oil from noni (<i>Morinda citrifolia</i>) seeds

West, Brett J.; Jensen, C. Jarakae; Westendorf, Johannes

doi:10.1111/j.1365-2621.2008.01802.x

Cited by 27 publications

(26 citation statements)

References 5 publications

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“…More recently, the fruit has been used to produce dietary supplements. French Polynesia has been a major source of this juice where noni fruit puree constitutes one of the area’s largest agricultural exports [ 12 ]. In fact, more than 21,000 metric tons of this puree was exported in the past decade [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

The Potential Health Benefits of Noni Juice: A Review of Human Intervention Studies

West

Deng

Isami³

et al. 2018

Foods

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Noni juice is a globally popular health beverage originating in the tropics. Traditional Tahitian healers believe the noni plant to be useful for a wide range of maladies, and noni juice consumers throughout the world have similar perceptions. Nevertheless, human clinical trials are necessary for a precise understanding of what the health benefits of noni juice are. A review of published human intervention studies suggests that noni juice may provide protection against tobacco smoke-induced DNA damage, blood lipid and homocysteine elevation as well as systemic inflammation. Human intervention studies also indicate that noni juice may improve joint health, increase physical endurance, increase immune activity, inhibit glycation of proteins, aid weight management, help maintain bone health in women, help maintain normal blood pressure, and improve gum health. Further, these studies point to notable antioxidant activity in noni juice, more so than other fruit juices which served as trial placebos. It is this antioxidant effect and its interaction with the immune system and inflammation pathways that may account for many of the observed health benefits of noni juice. However, the existing evidence does have some limitations as far as its general application to noni juice products; all the peer-reviewed human interventions studies to date have involved only one source of French Polynesian noni juice. Geographical factors and variations in processing methods are known to produce commercial noni juice products with divergent phytochemical and nutrient compositions. Therefore, other sources of noni products may have different toxicological and pharmacological profiles.

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Section: Introductionmentioning

confidence: 99%

The Potential Health Benefits of Noni Juice: A Review of Human Intervention Studies

West

Deng

Isami³

et al. 2018

Foods

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“…Such an effect may explain, at least in part, the inhibition of COX-2 enzymes by NSO. The possibility of the inhibitory activity being due to linoleic acid is supported by analyses published by West and colleagues [14] which showed that linoleic acid accounted for 89.9 ± 19.2 g/kg of dried noni seeds and 594.5 ± 60.5 g/kg of the crude seed oil. These quantities make NSO a rich source of linoleic acid.…”

Section: Discussionmentioning

confidence: 88%

“…This finding suggests that NSO has little or no potential for clogging up pores of the skin when used as a cosmetic ingredient. Analyses by West and colleagues [14] showed that NSO contains linoleic and oleic acids, which are considered healthy fatty acids. In fact, oleic fatty acid can be used in cooking of foods [26][27][28] and for formulations of various cosmetics [29][30][31][32][33].…”

Section: Discussionmentioning

confidence: 99%

“…Previously, no evidence of acute oral toxicity was observed for NSO, and it was non-genotoxic in the Salmonella typhimurium reverse mutation assay (Ames test) or the in vitro mammalian chromosomal aberration assay [14]. During the challenge phase of the repeat-insult patch test of NSO, there were no reactions in any of the 49 volunteers.…”

Section: Repeat Insult Patch Testmentioning

confidence: 94%

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Noni Seed Oil Topical Safety, Efficacy, and Potential Mechanisms of Action

Palu¹,

West²,

Jensen³

2012

JCDSA

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Background: Noni fruit and leaf juices were used to treat acne in Polynesian folk medicine. However, the potential benefit of noni seed oil (NSO) for human skin health is not as well known. Objective: The topical safety of NSO was evaluated in a repeat insult patch test with 49 adult volunteers. Comedogenicity was evaluated in 23 adolescent volunteers for four weeks. Anti-inflammatory activity was determined <i>in-vitro</i> with COX-2 and 5-LOX enzyme inhibition assays. Results: No reactions to NSO were observed in any of the volunteers. NSO also reduced the number of open and closed comedones in the comedogenicity test. NSO inhibited COX-2 and 5-LOX enzymes in a concentration dependent manner, but with COX-2 inhibition being more pronounced than 5-LOX. Conclusion: Noni seed oil is safe for topical use and is non-comedogenic. It also has potential anti-inflammatory activity, being a dual inhibitor of COX-2 and 5-LOX enzymes. These results indicate the potential utility of NSO for skin care applications, as well as warrant further investigation of efficacy in 5-LOX and COX-2 related pathophysiological conditions

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“…More recently, the fruit is used to produce a juice that is often consumed to improve overall health. A major source of this juice is French Polynesia where noni fruit puree constitutes one of the largest agricultural exports [12]. In fact, more than 21,000 metric tons of this puree was exported in the past decade [13].…”

Section: Introductionmentioning

confidence: 99%

The Potential Health Benefits of Noni Juice: A Review of Human Intervention Studies

West¹,

Deng²,

Isami³

et al. 2018

Preprint

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Noni juice is a globally popular health beverage that originates from the tropics. Traditional Tahitian healers believe the noni plant to be useful for a wide range of maladies, and noni juice consumers throughout the world have similar perceptions. Nevertheless, human clinical trials are necessary for an understanding of what the health benefits of noni juice truly are. A review of published human intervention studies suggest that noni juice may provide protection against tobacco smoke-induced DNA damage, blood lipid and homocysteine elevation, and systemic inflammation. Human interventions studies also suggest that noni juice may improve joint health, increase physical endurance, increase immune activity, inhibit glycation of proteins, aid weight management, help maintain bone health in women, help maintain normal blood pressure, and improve gum health. Further, these studies point to noni juice possessing notable antioxidant activity, more so than the other fruit juices that served as placebos. It is this antioxidant effect, and its interaction with the immune system and inflammation pathways, that may account for many of the observed health benefits of noni juice. However, the existing evidence does have some limitations in its application to noni juice products in general as all the peer-reviewed human interventions studies to-date have involved only one source of French Polynesian noni juice. Geographical factors and variations in processing methods are known to produce commercial noni juice products with divergent phytochemical and nutrient compositions. Therefore, other sources of noni products may have different toxicological and pharmacological profiles.

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A new vegetable oil from noni (Morinda citrifolia) seeds

Cited by 27 publications

References 5 publications

The Potential Health Benefits of Noni Juice: A Review of Human Intervention Studies

The Potential Health Benefits of Noni Juice: A Review of Human Intervention Studies

Noni Seed Oil Topical Safety, Efficacy, and Potential Mechanisms of Action

The Potential Health Benefits of Noni Juice: A Review of Human Intervention Studies

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