A new variation of in-vitro fertilization: intravaginal culture of human oocytes and cleavage stages

Sterzik, K.; Rosenbusch, B.; Sasse, V.; Wolf, A. S.; Beier, Henning M.; Lauritzen, C

doi:10.1093/humrep/4.suppl_1.83

Cited by 21 publications

(13 citation statements)

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“…INVO procedure has been used worldwide and results from cycles performed by infertility centers around the world, in countries such as France, Germany, The Netherlands, England, USA, and Japan, have been published [1, 2, 4–12]. More recently our center has pioneered the use of this procedure employing the INVOcell device within the Latin-American region [13] and has been leader in its recent introduction in countries such as Mexico, Guatemala, El Salvador, Nicaragua, Dominican Republic, Panama, Venezuela, Ecuador, Peru, Bolivia, and Brazil.…”

Section: Introductionmentioning

confidence: 99%

INVO Procedure: Minimally Invasive IVF as an Alternative Treatment Option for Infertile Couples

Lucena

Saa

Navarro

et al. 2012

The Scientific World Journal

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Intravaginal culture (IVC), also called INVO (intravaginal culture of oocytes), is an assisted reproduction procedure where oocyte fertilization and early embryo development are carried out within a gas permeable air-free plastic device, placed into the maternal vaginal cavity for incubation. In the present study we assessed the outcome of the INVO procedure, using the recently designed INVOcell device, in combination with a mild ovarian stimulation protocol. A total of 125 cycles were performed. On average 6.5 oocytes per cycle were retrieved, and a mean of 4.2 were placed per INVOcell device. The cleavage rate obtained after the INVO culture was 63%. The procedure yielded 40%, 31.2%, and 24% of clinical pregnancy, live birth, and single live birth rates per cycle, respectively. Our results suggest that the INVO procedure is an effective alternative treatment option in assisted reproduction that shows comparable results to those reported for existing IVF techniques.

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Section: Introductionmentioning

confidence: 99%

INVO Procedure: Minimally Invasive IVF as an Alternative Treatment Option for Infertile Couples

Lucena

Saa

Navarro

et al. 2012

The Scientific World Journal

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“…For example, expensive ovarian stimulant drugs could be forgone in favour of 'natural-cycle' IVF, where no hormonal stimulants are used (Shahin, 2007). Clinics could also attempt vaginal culture, in which oocytes are fertilized inside a capsule inserted into the female patient's vagina (Sterzik et al, 1989). This eliminates the need for an incubator and results in similar pregnancy rates as conventional approaches to IVF (Sterzik et al, 1989).…”

Section: Suggestions For Reformmentioning

confidence: 99%

Assisted reproduction in Indonesia: policy reform in an Islamic culture and developing nation

Purvis

2015

Reproductive BioMedicine Online

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This article considers how religious and economic factors shape assisted reproductive technology (ART) policy in Indonesia, the world's most populous Muslim country. Infertility clinic policies are grounded on both the views of the country's powerful Islamic coalition and those of the worldwide Islamic community. Indonesian government officials, physicians, and Islamic scholars have expressed concern over who can use ART and which procedures can be performed. Indonesia has also faced economic challenges related to ART, including inadequate health insurance coverage, inequitable access to ART, and maintenance of expensive ART infrastructure. The prohibitive price of infertility treatment and regional differences in the provision of health care prohibit most Indonesians from obtaining ART. In the absence of a shift in religious mores and a rapid reduction in poverty and inequality, Indonesia will need to adopt creative means to make ART both more available and less necessary as a solution to infertility. This paper suggests policy reforms to promote more affordable treatment methods and support preventative health programmes to reduce infertility rates. This country-specific analysis of the laws and customs surrounding ART in Indonesia reveals that strategies to reduce infertility must be tailored to a country's unique religious and economic climate.

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“…Such a system costs some € 6000, but a very simple system would also work. In the early days of IVF, some teams placed closed, tightly wrapped culture tubes in the woman's vagina [25,26], and pregnancies occurred. This option may be acceptable for 1‐day cultures up to the pronuclear stage.…”

Section: Laboratory Studies In the Low‐cost Ivf Modelmentioning

confidence: 99%

“…A very slimmed‐down version of IVF with vaginal culture [25,26] may be a way to avoid purchasing an incubator. After CC stimulation or during a natural cycle, the oocytes are collected when the largest follicles are about 18 mm in diameter and placed, together with spermatozoa prepared by swim‐up, in a tube containing a commercial culture medium.…”

Section: A Slimmed‐down Version Of Ivf With Vaginal Culturementioning

confidence: 99%

Cost‐effective approaches to in vitro fertilization: Means to improve access

Hovatta

Cooke²

2006

Intl J Gynecology & Obste

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Many childless couples would like to have access to in vitro fertilization (IVF) through public-sector programs, but such programs are scant because of the high costs that IVF entails today. A solution for health departments worldwide might be to leave IVF methods requiring expensive equipment and ovarian stimulating hormones - such as human recombinant gonadotropins, plus gonadotropin-releasing hormone analogues to prevent a surge of luteinizing hormone - to the private sector. Rather, health departments could focus on methods using less equipment and no ovarian stimulating agent at all if possible. If not possible, inexpensive clomiphene citrate could be used, combined with human menopausal gonadotropin if needed. Before embryo transfer, oocyte maturation could occur in vitro or in a makeshift incubator: a tube closed, wrapped, and left in the woman's vagina for 24 h. To prevent short- and long-term costs as well as possible lifelong problems, the transfer of multiple embryos should not be performed.

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A new variation of in-vitro fertilization: intravaginal culture of human oocytes and cleavage stages

Cited by 21 publications

References 0 publications

INVO Procedure: Minimally Invasive IVF as an Alternative Treatment Option for Infertile Couples

INVO Procedure: Minimally Invasive IVF as an Alternative Treatment Option for Infertile Couples

Assisted reproduction in Indonesia: policy reform in an Islamic culture and developing nation

Cost‐effective approaches to in vitro fertilization: Means to improve access

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