A new utilization of total flavonoids from Acer truncatum samara and leaves: Anti-aging and metabolic regulation

Zhang, Xiaoyue; Wang, Di-Sheng; Xue, Lianqing; Miao, Yanjun; Gao, Jin‐Ming; Zhang, Qiang

doi:10.1016/j.indcrop.2023.117207

Cited by 3 publications

(5 citation statements)

References 53 publications

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“…46 Furthermore, research has shown that DAF-16 has the ability to initiate the transcription of AAK-2, and results in one study suggested that DAF-16 may play a role in EGCG-induced life extension through AAK-2. 47 In addition, transcription factor SKN-1 can activate downstream genes jnk-1 and jkk-1 via the JNK MAPK pathway or regulate downstream sek-1 and nsy-1 via the p38 MAPK pathway. 48,49 Studies about mutant strains associated with stress and longevity revealed that lifespan-extending phenotypes were absent from the sek-1 , skn-1 , and sir-2.1 mutants under curcumin treatment, indicating the indispensability of those genes for curcumin-mediated longevity in nematodes.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of EGCG on acrolein-induced Caenorhabditis elegans and its mechanism of life extension

Song,

Liu,

Xie

et al. 2024

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Protective effects of EGCG on acrolein-induced Caenorhabditis elegans and its mechanism of life extension

Song,

Liu,

Xie

et al. 2024

Food Funct.

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“…The machine analysis and data analysis were performed according to the method we reported [ 30 ]. In brief, LC-HRMS was analyzed on a Q Extractive Focus instrument (Thermos Fisher Scientific, Waltham, MA, USA).…”

Section: Methodsmentioning

confidence: 99%

“…For instance, flavonoids isolated from Sc ameliorate pelvic inflammation by promoting autophagic cell reprogramming via the NLRP3 inflammation-mediated autophagy pathway [6]. The methanol extract of Sc root has neuroprotective effects against excitatory poisoning and cerebral ischemic injury, as well as Aβ (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)-induced cortical nerve injury in rats [7,8]. Sc polyphenols can also be used to prevent obesity and related metabolic diseases in mice [9].…”

Section: Introductionmentioning

confidence: 99%

Metabolic Regulations of Smilax china L. against β-Amyloid Toxicity in Caenorhabditis elegans

Yan,

Deng,

et al. 2024

Metabolites

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Smilax china L. (Chinaroot) is a natural herb that has multiple uses, such as being used to make tea and food. Both its roots and leaves have different uses due to their unique components. In this study, we analyzed the extract of S. china. roots using LC-HRMS and evaluated the neuroprotective effects and metabolic regulation of S. china on Caenorhabditis elegans. Chinaroot extract prolonged the life span of healthy nematodes, delayed the paralysis time of transgenic CL4176, and reduced the level of β-amyloid deposition in transgenic CL2006. The comprehensive analysis of metabolomics and qRT-PCR revealed that Chinaroot extract exerted neuroprotective effects through the valine, leucine and isoleucine degradation and fatty acid degradation pathways. Moreover, we first discovered that the expressions of T09B4.8, ech-7, and agxt-1 were linked to the neuroprotective effects of Chinaroot. The material exerted neuroprotective effects by modulating metabolic abnormalities in AD model C. elegans. Our study provides a new foundation for the development of functional food properties and functions.

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“…Naringin and apigenin can enhance the antioxidant capacity of the skin by reducing the levels of malondialdehyde and lipid peroxide, and increasing the catalase and total antioxidant capacity [113]. Total flavonoids from Acer truncatum leaves have been shown to be able to prevent oxidative stress caused by juglone by upregulating catalase superoxide dismutase activity and lowering malondialdehyde and ROS concentrations [114]. The in vitro antioxidant activity of flavonoid-rich ethanolic extract (EE) was examined and it was found that EE possessed good scavenging ability against 2-diphcnyl- Even though there has been significant progress in producing flavonoids by biosynthesis, the efficiency of flavonoid biosynthesis is still severely limited by the intricacy of natural product metabolic pathways and the limitations of current analytical methods.…”

Section: Antioxidant Effectsmentioning

confidence: 99%

“…Naringin and apigenin can enhance the antioxidant capacity of the skin by reducing the levels of malondialdehyde and lipid peroxide, and increasing the catalase and total antioxidant capacity [113]. Total flavonoids from Acer truncatum leaves have been shown to be able to prevent oxidative stress caused by juglone by upregulating catalase superoxide dismutase activity and lowering malondialdehyde and ROS concentrations [114]. The in vitro antioxidant activity of flavonoid-rich ethanolic extract (EE) was examined and it was found that EE possessed good scavenging ability against 2-diphcnyl-l-picrylhydrazyl (DPPH), 2,2 ′ -azinobis (3-ethylbenzothiazoline-6-sulfonic acid ammonium salt (ABTS), and hydroxyl radicals with IC 50 values of 296.95 ± 13.24 µg/mL, 94.31 ± 9.13 µg/mL, and 9.21 ± 0.15 mg/mL, respectively.…”

Section: Antioxidant Effectsmentioning

confidence: 99%

Advances in Flavonoid Research: Sources, Biological Activities, and Developmental Prospectives

Hao,

Yang,

Liu

et al. 2024

CIMB

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At present, the occurrence of a large number of infectious and non-communicable diseases poses a serious threat to human health as well as to drug development for the treatment of these diseases. One of the most significant challenges is finding new drug candidates that are therapeutically effective and have few or no side effects. In this respect, the active compounds in medicinal plants, especially flavonoids, are potentially useful compounds with a wide range of pharmacological activities. They are naturally present in nature and valuable in the treatment of many infectious and non-communicable diseases. Flavonoids are divided into fourteen categories and are mainly derived from plant extraction, chemical synthesis and structural modification, and biosynthesis. The structural modification of flavonoids is an important way to discover new drugs, but biosynthesis is currently considered the most promising research direction with the potential to revolutionize the new production pipeline in the synthesis of flavonoids. However, relevant problems such as metabolic pathway analyses and cell synthesis protocols for flavonoids need to be addressed on an urgent basis. In the present review, new research techniques for assessing the biological activities of flavonoids and the mechanisms of their biological activities are elucidated and their modes of interaction with other drugs are described. Moreover, novel drug delivery systems, such as nanoparticles, bioparticles, colloidals, etc., are gradually becoming new means of addressing the issues of poor hydrophilicity, lipophilicity, poor chemical stability, and low bioavailability of flavonoids. The present review summarizes the latest research progress on flavonoids, existing problems with their therapeutic efficacy, and how these issues can be solved with the research on flavonoids.

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A new utilization of total flavonoids from Acer truncatum samara and leaves: Anti-aging and metabolic regulation

Cited by 3 publications

References 53 publications

Protective effects of EGCG on acrolein-induced Caenorhabditis elegans and its mechanism of life extension

Protective effects of EGCG on acrolein-induced Caenorhabditis elegans and its mechanism of life extension

Metabolic Regulations of Smilax china L. against β-Amyloid Toxicity in Caenorhabditis elegans

Advances in Flavonoid Research: Sources, Biological Activities, and Developmental Prospectives

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