A new type of dual temperature sensitive triblock polymer (P(AM-co-AN)-b-PDMA-b-PNIPAM) and its self-assembly and gel behavior

Zhou, Cheng; Yan, Chao; Huang, Mingjun; Ling, Yi; Yang, Liming; Zhao, Guochen; Chen, Jie

doi:10.1039/d0nj06153k

Cited by 7 publications

(10 citation statements)

References 32 publications

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“…At low temperatures (< UCST), stable hydrogen bonds were formed between the polymers, allowing them to aggregate and form the micelles in the solution [ 30 ]. While at high temperatures (> UCST), the hydrogen bonds between the polymers were dissociated and the micelles were dissolved in water, resulting in the elevation of transmittance [ 31 ]. In addition, due to the different synchronization of hydrogen bonds in and between micelles, the transmittance curves did not coincide during heating and cooling procedure [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

Upper-critical solution temperature (UCST) polymer functionalized nanomedicine for controlled drug release and hypoxia alleviation in hepatocellular carcinoma therapy

Niu,

Fu,

Feng

et al. 2023

PLoS ONE

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Recently, bioinspired material such as nanoparticle has been successfully applied in the cancer therapy. However, how to precisely control the drug release from nanomedicine in tumor tissue and overcome the hypoxic microenvironment of tumor tissue is still an important challenge in the development of nanomedicine. In this work, a new type of drug-loaded nanoparticles P(AAm-co-AN)-AuNRs@CeO2-DOX (PA-DOX) was prepared by combining high-efficiency photothermal reagents, critical up-conversion temperature polymer layer and anti-cancer drug doxorubicin (DOX) for the treatment of hepatocellular carcinoma (HCC). In this system, CeO2 can decompose hydrogen peroxide to H2O and O2 alleviate the anaerobic microenvironment of liver cancer cells. As a photothermal reagent, AuNRs@CeO2 can convert near-infrared light into heat energy to achieve local heat to kill cancer cells and ablate solid tumors. In addition, the elevated temperature would enable the polymer layer to undergo a phase transition to release more DOX to achieve a controlled release mechanism, which will open up a new horizon for clinical cancer treatment.

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Section: Resultsmentioning

confidence: 99%

Upper-critical solution temperature (UCST) polymer functionalized nanomedicine for controlled drug release and hypoxia alleviation in hepatocellular carcinoma therapy

Niu,

Fu,

Feng

et al. 2023

PLoS ONE

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“…Recently, the discovery of novel UCST polymers has led to advancements in thermoresponsive block copolymers [ 331 – 332 ]. Zhang et al [ 333 ], Käfer et al [ 334 ], and Zhou et al [ 335 ] succeeded in embedding the nonionic UCST-type copolymer P(AAm- co -AN) into dual thermoresponsive (UCST–LCST) systems, which were complemented either by a PDMAEMA, PEG or PNIPAAm LCST block. In contrast to the use of zwitterionic polymers, a reversible, sharp UCST phase transition of the P(AAm- co -AN) block could be detected in pure water as well as buffer solutions of elevated ionic strength.…”

Section: Reviewmentioning

confidence: 99%

Constrained thermoresponsive polymers – new insights into fundamentals and applications

Flemming¹,

Münch²,

Fery³

et al. 2021

Beilstein J. Org. Chem.

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In the last decades, numerous stimuli-responsive polymers have been developed and investigated regarding their switching properties. In particular, thermoresponsive polymers, which form a miscibility gap with the ambient solvent with a lower or upper critical demixing point depending on the temperature, have been intensively studied in solution. For the application of such polymers in novel sensors, drug delivery systems or as multifunctional coatings, they typically have to be transferred into specific arrangements, such as micelles, polymer films or grafted nanoparticles. However, it turns out that the thermodynamic concept for the phase transition of free polymer chains fails, when thermoresponsive polymers are assembled into such sterically confined architectures. Whereas many published studies focus on synthetic aspects as well as individual applications of thermoresponsive polymers, the underlying structure–property relationships governing the thermoresponse of sterically constrained assemblies, are still poorly understood. Furthermore, the clear majority of publications deals with polymers that exhibit a lower critical solution temperature (LCST) behavior, with PNIPAAM as their main representative. In contrast, for polymer arrangements with an upper critical solution temperature (UCST), there is only limited knowledge about preparation, application and precise physical understanding of the phase transition. This review article provides an overview about the current knowledge of thermoresponsive polymers with limited mobility focusing on UCST behavior and the possibilities for influencing their thermoresponsive switching characteristics. It comprises star polymers, micelles as well as polymer chains grafted to flat substrates and particulate inorganic surfaces. The elaboration of the physicochemical interplay between the architecture of the polymer assembly and the resulting thermoresponsive switching behavior will be in the foreground of this consideration.

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“…UCST behavior is rarely observed under practically relevant conditions. However, relying on hydrogen bonding (HB‐UCST) it has been possible to prepare MSR polymers based on the UCST copolymers P(AAm‐ co ‐AN) 210,211 …”

Section: The Basic Monomers Toy Box: Plenty To Play Withmentioning

confidence: 99%

Playing construction with the monomer toy box for the synthesis of multi‐stimuli responsive copolymers by reversible deactivation radical polymerization protocols

D’Acunzo

Masci

2021

Journal of Polymer Science

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In this review article, we survey the 2016–June 2021 scientific literature on the synthesis of multi‐stimuli responsive (MSR) polymers, the main focus being on reversible deactivation radical polymerization techniques (RDRPs, also known as controlled radical polymerizations). In fact, along more than 40 years of extensive research, RDRPs have boosted the synthesis of stimuli‐responsive polymers. RDRPs are now robust, versatile, relatively user‐friendly and even interconvertible, thus allowing control over composition, sequence, and topology of polymers. Such control can afford materials with well‐defined responses to physical, chemical, and biological external stimuli. Furthermore, “click” reactions are used to combine macromolecular precursors or to introduce specific functional groups in the target structure. As a result, MSR polymers are obtained from diverse combinations of commercial or specially synthesized building blocks arranged at will into desired sequences and architectures. Thanks to this versatility, self‐assembling polymeric structures are designed either to respond to triggers and perform specific applicative tasks, or to investigate the influence of structural variables on the responsivity of polymers. The “green” trend emerging in the field of responsive polymers and RDRPs is also briefly discussed.

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A new type of dual temperature sensitive triblock polymer (P(AM-co-AN)-b-PDMA-b-PNIPAM) and its self-assembly and gel behavior

Cited by 7 publications

References 32 publications

Upper-critical solution temperature (UCST) polymer functionalized nanomedicine for controlled drug release and hypoxia alleviation in hepatocellular carcinoma therapy

Upper-critical solution temperature (UCST) polymer functionalized nanomedicine for controlled drug release and hypoxia alleviation in hepatocellular carcinoma therapy

Constrained thermoresponsive polymers – new insights into fundamentals and applications

Playing construction with the monomer toy box for the synthesis of multi‐stimuli responsive copolymers by reversible deactivation radical polymerization protocols

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