A new two dimensional copper (II) coordination complex with sulphonamide: Synthesis, crystal structure and DNA binding study

Synthesis and crystal structure determination of copper(II)-complex: In vitro DNA and HSA binding, pBR322 plasmid cleavage, cell imaging and cytotoxic studies

“…Ethidium bromide is a typical indicator of intercalation since it can form soluble complexes with nucleic acids emitting intense fluorescence in the presence of CT DNA due to the intercalation of the planar phenenthridinium ring between adjacent base pairs on the double helix. The enhanced fluorescence can be quenched upon the addition of the second molecule which could replace the bound EB or break the secondary structure of the DNA [21]. Upon addition of increasing concentration of 1 to CT DNA pretreated with EB ([DNA]/[EB] ¼ 1) solution, the emission band at 591 nm exhibited quenching of the emission intensity up to 49% of the initial fluorescence intensity when the molar ratio of the complex to CT-DNA (r ¼ [complex]/[CT-DNA]) range from 1.6 to 15.0 (Fig.…”

Synthesis and structure elucidation of a copper(II) Schiff-base complex: In vitro DNA binding, pBR322 plasmid cleavage and HSA binding studies

“…EB is one of the most sensitive fluorescence probes that show no apparent emission intensity in buffer solution because of solvent quenching. In fact the EB fluorescence intensity will be enhanced in the presence of DNA because of its intercalation into the helix, and it was quenched by the addition of another molecule either by replacing the EB and/or by accepting the excited-state electron of the EB through a photoelectron transfer mechanism [38]. The extent of reduction of the emission intensity gives a measure of the binding propensity of the complex to CT-DNA.…”

Synthesis, Characterization and DNA Binding Studies of (E)-1-((Pyridin-2-yl)methylidene) semicarbazide Mn(II), Co(II), Ni(II) and Cu(II) Complexes

“…The interaction of transition metal complexes with DNA continues to attract interest in relation to enzyme-DNA interaction and in the search for anticancer chemotherapeutic agents [29][30][31][32][33][34][35][36][37]. Transition metal complexes can bind to DNA via covalent and/or non-covalent interactions [29].…”

“…In view of above importance and in continuation of our research in the field of biologically active complexes [30][31][32][33], we herein report the syntheses, spectroscopic characterization and DNA binding studies of Mn(II), Co(II), Ni(II) and…”