A New Treatment of Barbiturate Intoxication

Massive Doses of Bemegride and Amiphennzole in Treatment of Barbiturate Poisoning

“…The value of bemegride and amiphenazole in the treatment of barbiturate poisoning has been fully established since their introduction by Shaw et al (1954) and Shulman et al (1955). Untoward effects from these drugs are rare, but in excessive dosage vomiting, convulsions, and psychic disturbances have been reported.…”

Some Aspects of the Pharmacology of 5‐phenylthiazolidine‐2: 4‐dione (2: 4‐dihydroxy‐5‐phenylthiazole)

“…(II) and Phenobarbitone (5-phenyl-5-ethylbarbituric acid, VI). Dolitrone, whose structure seems to combine the essential groupings of both these latter substances and whose hypnotic activity is likewise antagonized by Bemegride (/3-methyl-/;fethylglutarimide) (Shulman and Laycock, 1957), was recently introduced into the practice of anaesthesia by Lundy (1955) as an analgesic and mild narcotic producing a state of "controlled amnesia". Lande andBentley (1955), Lundgren (1956), McKeogh and Shaw (1956), Shaw, Simon, Cass, Shulman, Anstee and Nelson (1954), Shaw (1955), Shaw and Bentley (1955), Shaw and Shulman (1955), , Shulman (1956a), Shulman, Shaw, Cass and Whyte (1955), Shnhnan and Tiethewie (1956).…”

“…The concomitant use of D.A.P.T. was advocated because of its ability, in therapeutic doses, to potentiate the antibarbiturate action of Bemegride as well as minimizing the incidence of toxic symptoms (cerebral excitation) following the administration of excessive doses of this latter substance Shaw, 1955;Shulman et al, 1955).…”

The Michael-type Addition of 1-Cyanoacetyl-3,5-dimethylpyrazole to Arylmethylenecyanoacetamides

“…The discovery of the analeptic and sedative action of compounds 1 [6][7][8][9][10][11] stimulated the study of their preparation and properties. However, it has been found that the classic Guareschi method has some drawbacks, e.g.…”