A New Transkingdom Dimension to NO Signaling

Ma, Dong; Leulier, François

doi:10.1016/j.cmet.2019.02.008

Cited by 3 publications

(1 citation statement)

References 13 publications

(12 reference statements)

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“…OPN predominantly heightens inflammatory responses and disrupts glucose homeostasis in adipocytes and hepatocytes, which may further impair phosphatidylcholine and cholesterol metabolism and thus exacerbate nonalcoholic cirrhosis of the liver [ 64 , 70 ]. However, other studies showed that OPN can safeguard β-cells by lowering the production of iNOS and maintaining Ca 2+ homeostasis [ 71 ]. Studies have long shown that energy metabolism is regulated by OPN released by adipocytes, hepatocytes, and macrophages.…”

Section: Bone Cells and Global Energy Metabolismmentioning

confidence: 99%

Osteometabolism: Metabolic Alterations in Bone Pathologies

Srivastava

Sapra

Mishra³

2022

Cells

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Renewing interest in the study of intermediate metabolism and cellular bioenergetics is brought on by the global increase in the prevalence of metabolic illnesses. Understanding of the mechanisms that integrate energy metabolism in the entire organism has significantly improved with the application of contemporary biochemical tools for quantifying the fuel substrate metabolism with cutting-edge mouse genetic procedures. Several unexpected findings in genetically altered mice have prompted research into the direction of intermediate metabolism of skeletal cells. These findings point to the possibility of novel endocrine connections through which bone cells can convey their energy status to other metabolic control centers. Understanding the expanded function of skeleton system has in turn inspired new lines of research aimed at characterizing the energy needs and bioenergetic characteristics of these bone cells. Bone-forming osteoblast and bone-resorbing osteoclast cells require a constant and large supply of energy substrates such as glucose, fatty acids, glutamine, etc., for their differentiation and functional activity. According to latest research, important developmental signaling pathways in bone cells are connected to bioenergetic programs, which may accommodate variations in energy requirements during their life cycle. The present review article provides a unique perspective of the past and present research in the metabolic characteristics of bone cells along with mechanisms governing energy substrate utilization and bioenergetics. In addition, we discussed the therapeutic inventions which are currently being utilized for the treatment and management of bone-related diseases such as osteoporosis, rheumatoid arthritis (RA), osteogenesis imperfecta (OIM), etc., by modulating the energetics of bone cells. We further emphasized on the role of GUT-associated metabolites (GAMs) such as short-chain fatty acids (SCFAs), medium-chain fatty acids (MCFAs), indole derivates, bile acids, etc., in regulating the energetics of bone cells and their plausible role in maintaining bone health. Emphasis is importantly placed on highlighting knowledge gaps in this novel field of skeletal biology, i.e., “Osteometabolism” (proposed by our group) that need to be further explored to characterize the physiological importance of skeletal cell bioenergetics in the context of human health and bone related metabolic diseases.

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Section: Bone Cells and Global Energy Metabolismmentioning

confidence: 99%

Osteometabolism: Metabolic Alterations in Bone Pathologies

Srivastava

Sapra

Mishra³

2022

Cells

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Enhancing S-nitrosoglutathione reductase decreases S-nitrosylation of Drp1 and reduces neuronal apoptosis in experimental subarachnoid hemorrhage both in vivo and in vitro

Wang

You

et al. 2022

Brain Research Bulletin

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Endocrine role of bone in the regulation of energy metabolism

et al. 2021

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AbstractsBone mainly functions as a supportive framework for the whole body and is the major regulator of calcium homeostasis and hematopoietic function. Recently, an increasing number of studies have characterized the significance of bone as an endocrine organ, suggesting that bone-derived factors regulate local bone metabolism and metabolic functions. In addition, these factors can regulate global energy homeostasis by altering insulin sensitivity, feeding behavior, and adipocyte commitment. These findings may provide a new pathological mechanism for related metabolic diseases or be used in the diagnosis, treatment, and prevention of metabolic diseases such as osteoporosis, obesity, and diabetes mellitus. In this review, we summarize the regulatory effect of bone and bone-derived factors on energy metabolism and discuss directions for future research.

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A New Transkingdom Dimension to NO Signaling

Cited by 3 publications

References 13 publications

Osteometabolism: Metabolic Alterations in Bone Pathologies

Osteometabolism: Metabolic Alterations in Bone Pathologies

Enhancing S-nitrosoglutathione reductase decreases S-nitrosylation of Drp1 and reduces neuronal apoptosis in experimental subarachnoid hemorrhage both in vivo and in vitro

Endocrine role of bone in the regulation of energy metabolism

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