A New Toxicant Occurring Naturally in Certain Samples of Plant Foodstuffs

Franke, Kurt W.

doi:10.1093/jn/10.3.233

Cited by 23 publications

(19 citation statements)

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“…The army horses that grazed freely around the fort suffered from a necrotic hoof malady and excessive losses of long hair in the tail and mane. Franke reported in the mid 1930s that the disease resulted from livestock eating seleniferous plants, which accumulated high levels of selenium from the soil [3]. …”

Section: Selenium In Animal Nutrition and Human Healthmentioning

confidence: 99%

Selenium and selenocysteine: roles in cancer, health, and development

Hatfield¹,

Tsuji²,

Carlson³

et al. 2014

Trends in Biochemical Sciences

590

343

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The many biological and biomedical effects of selenium are relatively unknown outside the selenium field. This fascinating element, initially described as a toxin, was subsequently shown to be essential for health and development. By the mid 1990s, selenium emerged as one of the most promising cancer chemopreventive agents, but subsequent human clinical trials yielded contradictory results. However, basic research on selenium continued to move at a rapid pace elucidating its many roles in health, development, and cancer prevention and promotion. Dietary selenium acts principally through selenoproteins, most of which are oxidoreductases involved in diverse cellular functions.

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Section: Selenium In Animal Nutrition and Human Healthmentioning

confidence: 99%

Selenium and selenocysteine: roles in cancer, health, and development

Hatfield¹,

Tsuji²,

Carlson³

et al. 2014

Trends in Biochemical Sciences

590

343

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“…The toxic effects of selenium were first described in South Dakota (USA), where chickens ( Gallus domesticus ) were observed to have poor reproductive success as a result of chick teratogenesis and mortality when fed grains from specific sources [1]. Subsequent studies identified elevated selenium content in the grains as the cause of the observed effects [2].…”

Section: Introductionmentioning

confidence: 99%

Analysis of field and laboratory data to derive selenium toxicity thresholds for birds

Adams¹,

Brix²,

Edwards

et al. 2003

Enviro Toxic and Chemistry

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In this paper, we critically evaluate the statistical approaches and datasets previously used to derive chronic egg selenium thresholds for mallard ducks (laboratory data) and black-necked stilts (field data). These effect concentration thresholds of 3%, 10% (EC10), or 20% have been used by regulatory agencies to set avian protection criteria and site remediation goals, thus the need for careful assessment of the data. The present review indicates that the stilt field dataset used to establish a frequently cited chronic avian egg selenium threshold of 6 mg/kg dry weight lacks statistical robustness (r2 = 0.19-0.28 based on generalized linear models), suggesting that stilt embryo sensitivity to selenium is highly variable or that factors other than selenium are principally responsible for the increase in effects observed at the lower range of this dataset. Hockey stick regressions used with the stilt field dataset improve the statistical relationship (r2 = 0.90-0.97) but result in considerably higher egg selenium thresholds (EC10 = 21-31 mg/kg dry wt). Laboratory-derived (for mallards) and field-derived (for stilts) teratogenicity EC10 values are quite similar (16-24 mg/kg dry wt). Laboratory data regarding mallard egg inviability and duckling mortality data provide the most sensitive and statistically robust chronic threshold (EC10) with logit, probit, and hockey stick regressions fitted to laboratory data, resulting in mean egg selenium EC10 values of 12 to 15 mg/kg dry weight (r2 = 0.75-0.90).

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“…The presence of selenium in protein as a component in the diet of mammals was not anticipated from its early history. For example, in the 1930s, selenium was recognized as a toxin in livestock that caused severe illness and, if left untreated, death (Franke, ,b). Furthermore, this element was later thought to cause cancer in laboratory animals (reviewed in Combs and Combs, ).…”

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confidence: 99%

Analysis of Selenocysteine‐Containing Proteins

Gladyshev

Hatfield

2000

CP Protein Science

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Representatives of three primary life domains--bacteria, archaea, and eukaryotes--possess specific selenium-containing proteins. The majority of naturally occurring selenoproteins contain an amino acid, selenocysteine, that is incorporated into protein in response to the code word UGA. The presence of selenium in natural selenoproteins and in proteins in which this element is introduced by chemical or biological manipulations provides additional opportunities for characterizing structure, function, and mechanism of action. This unit provides an overview of known selenocysteine-containing proteins, examples of targeted incorporation of selenium into proteins, and methods specific for selenoprotein identification and characterization.

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A New Toxicant Occurring Naturally in Certain Samples of Plant Foodstuffs

Cited by 23 publications

References 0 publications

Selenium and selenocysteine: roles in cancer, health, and development

Selenium and selenocysteine: roles in cancer, health, and development

Analysis of field and laboratory data to derive selenium toxicity thresholds for birds

Analysis of Selenocysteine‐Containing Proteins

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