A New Toxicant Occurring Naturally in Certain Samples of Plant Foodstuffs

Franke, Kurt W.; Potter, Van R.

doi:10.1093/jn/8.6.615

Cited by 46 publications

(21 citation statements)

References 3 publications

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“…where L ϭ likelihood of model with intercept only 0 L ϭ likelihood of full model (intercept and slope) 1 We did not utilize the frequently used Hosmer and Le-Deriving egg selenium toxicity thresholds for birds Environ. Toxicol.…”

Section: Statistical Analysis Of Laboratory and Field Datamentioning

confidence: 99%

Analysis of Field and Laboratory Data to Derive Selenium Toxicity Thresholds for Birds

Adams¹,

Brix²,

Edwards³

et al. 2003

Environ Toxicol Chem

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In this paper, we critically evaluate the statistical approaches and datasets previously used to derive chronic egg selenium thresholds for mallard ducks (laboratory data) and black-necked stilts (field data). These effect concentration thresholds of 3%, 10% (EC10), or 20% have been used by regulatory agencies to set avian protection criteria and site remediation goals, thus the need for careful assessment of the data. The present review indicates that the stilt field dataset used to establish a frequently cited chronic avian egg selenium threshold of 6 mg/kg dry weight lacks statistical robustness (r2 = 0.19-0.28 based on generalized linear models), suggesting that stilt embryo sensitivity to selenium is highly variable or that factors other than selenium are principally responsible for the increase in effects observed at the lower range of this dataset. Hockey stick regressions used with the stilt field dataset improve the statistical relationship (r2 = 0.90-0.97) but result in considerably higher egg selenium thresholds (EC10 = 21-31 mg/kg dry wt). Laboratory-derived (for mallards) and field-derived (for stilts) teratogenicity EC10 values are quite similar (16-24 mg/kg dry wt). Laboratory data regarding mallard egg inviability and duckling mortality data provide the most sensitive and statistically robust chronic threshold (EC10) with logit, probit, and hockey stick regressions fitted to laboratory data, resulting in mean egg selenium EC10 values of 12 to 15 mg/kg dry weight (r2 = 0.75-0.90).

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Section: Statistical Analysis Of Laboratory and Field Datamentioning

confidence: 99%

Analysis of Field and Laboratory Data to Derive Selenium Toxicity Thresholds for Birds

Adams¹,

Brix²,

Edwards³

et al. 2003

Environ Toxicol Chem

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“…Our understanding of the significance and complex metabolic role of Se in human nutrition has evolved substantially in the past century. Historically, Se was regarded as a naturally occurring toxic element causing signs in farm animals such as loss of hooves and hair, emaciation, stiffness, and even death [1], and was reported to be a carcinogen [2]. However, this perspective has undergone radical transformation in the past 50 years.…”

Section: Introductionmentioning

confidence: 99%

Selenium Supplementation and Cancer Prevention

Davis

2012

Curr Nutr Rep

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The essential trace element selenium has been shown to have cancer preventive potential by a converging body of epidemiologic and preclinical studies. Although randomized controlled trials suggest a benefit against liver cancer, results at other sites are not as consistent. The Nutritional Prevention of Cancer Trial provided evidence that selenium-enriched yeast can protect against total cancer incidence and the incidence of prostate, lung, and colorectal cancer. In contrast, in the Selenium and Vitamin E Cancer Prevention Trial (SELECT), selenomethionine provided no protection against prostate, lung, or colorectal cancer. Results from these trials suggest that the cancer protective effects of selenium probably depend on the baseline selenium status of the individual, chemical form of selenium utilized, gender, and genetic polymorphisms in selenoproteins or in cancer-related processes.

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“…Until 1957, knowledge of the biological significance of selenium was limited to its toxicity (6,25). Today, it is known to be an essential nutrient.…”

Section: Introductionmentioning

confidence: 99%

Selenium Content and Distribution in Bovine and Human Milk from Different Regions of Poland

Debski

Zarski

Milner

1992

Journal of Veterinary Medicine Series A

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Summary Human milk and bulk cow's milk samples from 3 different areas of central Poland were analized for their Se content. Cow's milk specimens were also analyzed for Se distribution and GSH‐Px activity. Mature human milk contained 34–68% more Se than bulk cow's milk obtained from analogous areas of central Poland. Comparison of literature values suggest, that human and cow's milk from vicinity of Warsaw and Piotrków Trubunalski were Se‐adequate but milk from Siedlce area was Se‐deficient. Glutathione peroxidase activity accounted for 25–31% of the total peroxidase activity of cow's milk. The majority of the Se was found in the whey fraction. It was suggested that the participation of the casein fraction in total milk selenium increased faster than milk Se content. Cow's milk obtained near Warsaw had a 2‐times higher concentration of Se than in milk from Siedlce but the content of this microelement in the casein fraction (pellet) was 3‐times higher.

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A New Toxicant Occurring Naturally in Certain Samples of Plant Foodstuffs

Cited by 46 publications

References 3 publications

Analysis of Field and Laboratory Data to Derive Selenium Toxicity Thresholds for Birds

Analysis of Field and Laboratory Data to Derive Selenium Toxicity Thresholds for Birds

Selenium Supplementation and Cancer Prevention

Selenium Content and Distribution in Bovine and Human Milk from Different Regions of Poland

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