A new thin-layer chromatographic method for analysis of zolpidem and zopiclone

Pushpalatha, P. B.; Sarin, Rakesh K.; Rao, Mesineni Anand; Baggi, T.R.

doi:10.1556/jpc.22.2009.6.12

Cited by 10 publications

(5 citation statements)

References 9 publications

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“…Most of the ICH Q3C solvents can be resolved by the Agilent DB-624 column. To obtain efficient separation and sample sensitivity, a number of GC parameters were evaluated when developing this method, such as the GC oven temperature gradient, carrier gas flow rate and sample split ratio: initial temperature 40 O C at different holding time (5,10,15, and 20 min), temperature ramping rate (5, 8, 10, 20 O C/min up to 150 O C), carrier flow rate (5, 6 and 7 mL/min) and split ratio (splitless or 1 to1-5 ratio). Our data indicated that the GC parameters listed in Section 2.2 were the most efficient combination for separation and sensitivity of this method.…”

Section: Optimization Of Gc Conditionsmentioning

confidence: 99%

“…Techniques for the determination of zopiclone in tablets include polarographic [7,8], HPLC and UV [9][10] methods. As an official compound in British pharmacopeia (BP), zopiclone is assayed by nonaqueous titrimetric method with potentiometric detection of end point for pure form and HPLC method for tablets [11], Literature survey also reveals many analytical methods for determination of zopiclone [12][13][14][15][16][17][18][19][20][21]. Zopiclone tablets are a film coated tablets, where isopropyl alcohol (IPA) and methylene chloride (MDC) are used during coating.…”

Section: Introductionmentioning

confidence: 99%

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Analytical Method Development and Validation for Determination of Residual Solvent in Zopiclone Tablets by Headspace Gas Chromatography

Shinde¹,

Bhalgat²,

Padwal³

et al. 2016

Eurasian J Anal Chem

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A simple and sensitive headspace gas chromatographic method has been developed and validated for simultaneous determination of isopropyl alcohol and methylene chloride in zopiclone tablets. The separation was achieved on 75 m long DB-624 fused silica column, 0.53 mm inner diameter and 3 μ film thickness using nitrogen as a carrier gas at 6 ml/min flow and FID as a detector. The developed gas chromatographic method offers symmetric peak shape, good resolution and reasonable retention time for all the solvents. The limit of detection of isopropyl alcohol and methylene chloride was found to be 250 μg/tablet and 90 μg/tablet, respectively.

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Section: Optimization Of Gc Conditionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analytical Method Development and Validation for Determination of Residual Solvent in Zopiclone Tablets by Headspace Gas Chromatography

Shinde¹,

Bhalgat²,

Padwal³

et al. 2016

Eurasian J Anal Chem

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“…Zolpidem and zopiclone are hypnotic reagents and can be used as potential drugs. Pushpalatha et al [ 78 ] applied 0.5% solution of chloranilic acid in 1,4-dioxane for the detection of zolpidem and zopiclone on silica gel 60. Colored complex spots of zolpidem and zopiclone with chloranilic acid are formed in nonaqueous medium.…”

Section: Visualizing Effects For Different Substances Including Drmentioning

confidence: 99%

Detection Progress of Selected Drugs in TLC

Pyka

2014

BioMed Research International

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This entry describes applications of known indicators and dyes as new visualizing reagents and various visualizing systems as well as photocatalytic reactions and bioautography method for the detection of bioactive compounds including drugs and compounds isolated from herbal extracts. Broadening index, detection index, characteristics of densitometric band, modified contrast index, limit of detection, densitometric visualizing index, and linearity range of detected compounds were used for the evaluation of visualizing effects of applied visualizing reagents. It was shown that visualizing effect depends on the chemical structure of the visualizing reagent, the structure of the substance detected, and the chromatographic adsorbent applied. The usefulness of densitometry to direct detection of some drugs was also shown. Quoted papers indicate the detection progress of selected drugs investigated by thin-layer chromatography (TLC).

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“…Literature review revealed many analytical methods for the determination of ZPC including spectrophotometry [3], HPLC [3][4][5][6][7][8][9], GC [9][10][11][12], TLC [13], ion-selective electrode [14] and polarographic methods [14,15].…”

Section: Introductionmentioning

confidence: 99%

“…A comprehensive literature search revealed that many of the reported methods failed to separate the parent drug from its degradation product and thus lack the stability-indicating nature [3][4][5][6][7][9][10][11][12][13][14][15]. On the other hand, few methods were applied as stability-indicating assays for ZPC, those methods are either not sufficiently sensitive to detect trace amounts of ACP in ZPC drug substance [16][17][18], or even they are time consuming requiring long run time to separate the drug from its degradation product [8].…”

Section: Introductionmentioning

confidence: 99%