A new thermography-based approach to early detection of cancer utilizing magnetic nanoparticles theory simulation and in vitro validation

Levy, Arie; Dayan, Abraham; Ben‐David, Moshe; Gannot, Israel

doi:10.1016/j.nano.2010.06.007

Cited by 46 publications

(25 citation statements)

References 14 publications

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“…Skin thermography is an objective and non-invasive procedure that measures temperature distribution using a thermal imager that receives and processes the infrared radiation emitted by the body surface [10]. The scientific use of thermography began in medical research, in which it has been used to diagnose vascular disease [11], inflammation [12], tumors [6,13], metabolic disorders and abnormalities in body temperature [12]. In the field of physical activity and sports, some studies have used the technique to study differences in thermogenesis between young and elderly people [14], the effect of exercise on hand temperature [8], and the distribution and variation of T SK during progressive exercise [4].…”

Section: Introductionmentioning

confidence: 99%

Time required to stabilize thermographic images at rest

Marins¹,

Moreira²,

Cano³

et al. 2014

Infrared Physics & Technology

109

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h i g h l i g h t sStandardizing the acclimatization time is crucial for a right T SK assessment by IRT. Time for reaching T SK balance in rest is different for young men and women. 10 min is enough for acclimatization when the external temperatures are not extreme. a r t i c l e i n f oArticle history: Received 6 November 2012 Available online 3 March 2014Keywords: Thermoregulation Thermography Thermal imaging Temperature a b s t r a c t Thermography for scientific research and practical purposes requires a series of procedures to obtain images that should be standardized; one of the most important is the time required for acclimatization in the controlled environment. Thus, the objective of this study was to identify the appropriate acclimatization time in rest to reach a thermal balance on young people skin. Forty-four subjects participated in the study, 18 men (22.3 ± 3.1 years) and 26 women (21.7 ± 2.5 years). Thermographic images were collected using a thermal imager (Fluke Ò ), totaling 44 images over a period of 20 min. The skin temperature (T SK ) was measured at the point of examination which included the 0 min, 2, 4, 6, 8, 10, 12, 14, 16, 18 and 20. The body regions of interest (ROI) analyzed included the hands, forearms, arms, thighs, legs, chest and abdomen. We used the Friedman test with post hoc Dunn's in order to establish the time at rest required to obtain a T SK balance and the Mann-Whitney test was used to compare age, BMI, body fat percentage and temperature variations between men and women, considering always a significance level of p < 0.05. Results showed that women had significantly higher temperature variations than men (p < 0.01) along the time. In men, only the body region of the abdomen obtained a significant variance (p < 0.05) on the analyzed period, both in the anterior and posterior part. In women, the anterior abdomen and thighs, and the posterior part of the hands, forearms and abdomen showed significant differences (p < 0.05). Based on our results, it can be concluded that the time in rest condition required reaching a T SK balance in young men and women is variable, but for whole body analysis it is recommended at least 10 min for both sexes.

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Section: Introductionmentioning

confidence: 99%

Time required to stabilize thermographic images at rest

Marins¹,

Moreira²,

Cano³

et al. 2014

Infrared Physics & Technology

109

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“…An aliquot of C1C2C3@dex nanoparticles (20,25,30 or 35 µL), diluted to 50 µL with water, was mixed with 50 µL of Matrigel™ (BD Matrigel™ Basement Membrane Matrix ; Becton, Dickinson and Company, San José, CA, USA) at temperature near 4°C. Previously, it was checked that Matrigel™ diluted twice still jellified when raising temperature to 37°C.…”

Section: In Vitro Mtn Experiments (Phantoms)mentioning

confidence: 99%

“…Thermal characteristics of the different tissues were obtained from the literature [25]. Figure 5 shows the modeling results for MTN concentration of 35 g/L in 100 µL Matrigel™ pseudo-tumors located below the skin.…”

Section: In Silico Modeling Of Temperature Distribution In Mtn-contaimentioning

confidence: 99%

In Vivo Imaging of Local Gene Expression Induced by Magnetic Hyperthermia

Sandre¹,

Genevois²,

Garaio³

et al. 2017

Preprint

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Abstract:The present work aims to demonstrate that colloidal dispersions of magnetic iron oxide nanoparticles stabilized with dextran macromolecules placed in an alternating magnetic field can not only produce heat, but also that these particles could be used in vivo for local and non-invasive deposition of a thermal dose sufficient to trigger thermo-induced gene expression. Iron oxide nanoparticles were first characterized in vitro on a bio-inspired setup, and then they were assayed in vivo using a transgenic mouse strain expressing the luciferase reporter gene under transcriptional control of a thermosensitive promoter. Iron oxide nanoparticles dispersions were applied topically on the mouse skin or injected sub-cutaneously with Matrigel™ to generate so called pseudo tumors. Temperature was monitored continuously with a feedback loop to control the power of the magnetic field generator and to avoid overheating. Thermo-induced luciferase expression was followed by bioluminescence imaging 6 hours after heating. We showed that dextran-coated magnetic iron oxide nanoparticles dispersions were able to induce in vivo mild hyperthermia compatible with thermo-induced gene expression in surrounding tissues and without impairing cell viability. These data open new therapeutic perspectives for using mild magnetic hyperthermia as non-invasive modulation of tumor microenvironment by local thermo-induced gene expression or drug release.

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“…22,25 Moreover, fiberoptic cables are invasive, implicating that any sample of interest needs to be compliant enough to be investigated. Thermal imaging -or thermography -is another option which provides a two-dimensional, 26 non-invasive thermal overview of the sample surface, 27 offering the possibility of investigating several samples at once along with controls. However, thermal waves from localized hotspots diffuse rapidly and blur the location of the heat sources.…”

Section: Introductionmentioning

confidence: 99%

A lock-in-based method to examine the thermal signatures of magnetic nanoparticles in the liquid, solid and aggregated states

et al. 2016

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We propose a new methodology based on lock-in thermography to study and quantify the heating power of magnetic nanoparticles. Superparamagnetic iron oxide nanoparticles exposed to a modulated alternating magnetic field were used as model materials to demonstrate the potency of the system. Both quantitative and qualitative information on their respective heating power was extracted at high thermal resolutions under increasingly complex conditions, including nanoparticles in the liquid, solid and aggregated states. Compared to conventional techniques, this approach offers a fast, sensitive and non-intrusive alternative to investigate multiple and dilute specimens simultaneously, which is essential for optimizing and accelerating screening procedures and comparative studies.

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A new thermography-based approach to early detection of cancer utilizing magnetic nanoparticles theory simulation and in vitro validation

Cited by 46 publications

References 14 publications

Time required to stabilize thermographic images at rest

Time required to stabilize thermographic images at rest

In Vivo Imaging of Local Gene Expression Induced by Magnetic Hyperthermia

A lock-in-based method to examine the thermal signatures of magnetic nanoparticles in the liquid, solid and aggregated states

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