A new therapeutic potential for cancers: One CAR with 2 different engines!

Sheikhi, Abdolkarim; Jafarzadeh, Abdollah

doi:10.1080/21645515.2017.1314874

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…Since cancer cells proliferate rapidly and are resistant to apoptosis, with a strong relationship to poor dietary habits, it is critical to investigate dietary components, particularly probiotics such as kefir as a possible therapeutic option for mitigating cancer cell growth [136]. During neoplastic growth, tumor cells evade the immune response, and probiotic bacteria have been found to promote immune system effector activities in co-cultures with peripheral blood mononuclear cells (PBMCs), as evidenced by cytokine profiles [137,138].…”

Section: Cancermentioning

confidence: 99%

Nutritional Characteristics, Health Impact, and Applications of Kefir

Apalowo,

Adegoye,

Mbogori

et al. 2024

Foods

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A global epidemiological shift has been observed in recent decades, characterized by an increase in age-related disorders, notably non-communicable chronic diseases, such as type 2 diabetes mellitus, cardiovascular and neurodegenerative diseases, and cancer. An appreciable causal link between changes in the gut microbiota and the onset of these maladies has been recognized, offering an avenue for effective management. Kefir, a probiotic-enriched fermented food, has gained significance in this setting due to its promising resource for the development of functional or value-added food formulations and its ability to reshape gut microbial composition. This has led to increasing commercial interest worldwide as it presents a natural beverage replete with health-promoting microbes and several bioactive compounds. Given the substantial role of the gut microbiota in human health and the etiology of several diseases, we conducted a comprehensive synthesis covering a total of 33 investigations involving experimental animal models, aimed to elucidate the regulatory influence of bioactive compounds present in kefir on gut microbiota and their potential in promoting optimal health. This review underscores the outstanding nutritional properties of kefir as a central repository of bioactive compounds encompassing micronutrients and amino acids and delineates their regulatory effects at deficient, adequate, and supra-nutritional intakes on the gut microbiota and their broader physiological consequences. Furthermore, an investigation of putative mechanisms that govern the regulatory effects of kefir on the gut microbiota and its connections with various human diseases was discussed, along with potential applications in the food industry.

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Section: Cancermentioning

confidence: 99%

Nutritional Characteristics, Health Impact, and Applications of Kefir

Apalowo,

Adegoye,

Mbogori

et al. 2024

Foods

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Kefir: a powerful probiotics with anticancer properties

et al. 2017

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Probiotics and fermented milk products have attracted the attention of scientists from various fields, such as health care, industry and pharmacy. In recent years, reports have shown that dietary probiotics such as kefir have a great potential for cancer prevention and treatment. Kefir is fermented milk with Caucasian and Tibet origin, made from the incubation of kefir grains with raw milk or water. Kefir grains are a mixture of yeast and bacteria, living in a symbiotic association. Antibacterial, antifungal, anti-allergic and anti-inflammatory effects are some of the health beneficial properties of kefir grains. Furthermore, it is suggested that some of the bioactive compounds of kefir such as polysaccharides and peptides have great potential for inhibition of proliferation and induction of apoptosis in tumor cells. Many studies revealed that kefir acts on different cancers such as colorectal cancer, malignant T lymphocytes, breast cancer and lung carcinoma. In this review, we have focused on anticancer properties of kefir.

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