A new tetranuclear copper(II) complex using a Schiff base ligand: Synthesis, structural, and magnetic studies

Aouaidjia, Fatima; Messai, Amel; Siab, R.; Ayesh, Ahmad I.

doi:10.1016/j.poly.2017.05.043

Cited by 9 publications

(6 citation statements)

References 67 publications

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“…Experimental data: FT-IR (KBr, cm À1 ): 1601 m (>C=N), 1519s (C=C), 1403 m (C-N Phen ) 1259 m (OCH 3 ), 1215 m (C-O), 474 s (Cu-N) UV-Vis for complex in DMF: λ max , nm, (ε, M À1 cm À1 ): 336 nm (19,860), 352 nm (18,750)…”

Section: Synthesis Of [Cu 3 (Napxshz) 2 (Phen) 2 ] (1)mentioning

confidence: 99%

“…[ 8,9 ] A variety of copper (II) complexes exhibit antibacterial, antifungal and antitumor properties. [ 10–14 ] Copper (II) also forms dinuclear and trinuclear, [ 15,16 ] tetranuclear [ 17,18 ] and polynuclear complexes with interesting applications. [ 19 ]…”

Section: Introductionmentioning

confidence: 99%

“…(II) complexes exhibit antibacterial, antifungal and antitumor properties. [10][11][12][13][14] Copper (II) also forms dinuclear and trinuclear, [15,16] tetranuclear [17,18] and polynuclear complexes with interesting applications. [19] Many copper (II) mononuclear or dinuclear complexes with NSAIDs bearing a carboxylate moiety as ligands have been synthesised and characterised.…”

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confidence: 99%

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A trinuclear copper (II) complex of naproxen‐appended salicylhydrazide: Synthesis, crystal structure, DNA binding and molecular docking study

Bhattacherjee

Roy

Naskar

et al. 2021

Applied Organom Chemis

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A trinuclear copper complex [Cu 3 (napxshz) 2 (phen) 2 ] has been synthesised using a tribasic naproxen-appended ligand [propanoyl) benzohydrazide] and 1,10-phenanthroline. The complex was characterised by different spectroscopic methods such as Fouriertransform infrared (FT-IR), ultraviolet-visible (UV-Vis) and electrospray ionisation (ESI)-mass spectroscopy. The solid-state structure of the ligand and complex 1 was established by single-crystal X-ray diffraction analysis. The interaction of the complex and the ligand with DNA was investigated by UV-visible spectroscopy and fluorometric titrations. The calculated binding constants (K b ) of the complex and the ligand with ct-DNA show that the complex has a higher binding affinity than the ligand H 3 napxshz. Quantum chemical calculations were performed to understand the structural aspects of the complex and its interactions with DNA. The molecular docking study reveals the interaction between DNA, and the complex is in intercalative mode.

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Section: Synthesis Of [Cu 3 (Napxshz) 2 (Phen) 2 ] (1)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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A trinuclear copper (II) complex of naproxen‐appended salicylhydrazide: Synthesis, crystal structure, DNA binding and molecular docking study

Bhattacherjee

Roy

Naskar

et al. 2021

Applied Organom Chemis

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“…Many polynuclear complexes of transition metals with various structures can be generated, depending on the disposition of the metal ions and the donor sites (N or O). Trimers (Zhang et al, 2009), square shapes (Aouaidjia et al, 2017), cyclic forms (Acevedo-Chá vez et al, 2002) and cubans (Shit et al, 2013) have been reported that have potential applications in the field of magnetism (Shit et al, 2013), catalysis (Okeke et al, 2018) and biomimetic synthesis (Wu et al, 2004). By extension, the introduction of an ethoxy-carbonyl group in the ortho position of the pyridine gives a ligand that can have a similar behavior to -amino acid esters.…”

Section: Chemical Contextmentioning

confidence: 99%

Crystal structures of two Cu^II compounds: catena-poly[[chloridocopper(II)]-μ-N-[ethoxy(pyridin-2-yl)methylidene]-N′-[oxido(pyridin-3-yl)methylidene]hydrazine-κ⁴ N,N′,O:N′′] and di-μ-chlorido-1:4κ² Cl:Cl-2:3κ² Cl:Cl-dichlorido-2κCl,4κCl-bis[μ₃-ethoxy(pyridin-2-yl)methanolato-1:2:3κ³

Sall

Tamboura

et al. 2019

Acta Cryst E

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Two CuII complexes [Cu(C14H13N4O2)Cl] n , I, and [Cu4(C8H10NO2)4Cl4] n , II, have been synthesized. In the structure of the mononuclear complex I, each ligand is coordinated to two metal centers. The basal plane around the CuII cation is formed by one chloride anion, one oxygen atom, one imino and one pyridine nitrogen atom. The apical position of the distorted square-pyramidal geometry is occupied by a pyridine nitrogen atom from a neighbouring unit, leading to infinite one-dimensional polymeric chains along the b-axis direction. Each chain is connected to adjacent chains by intermolecular C—H...O and C—H...Cl interactions, leading to a three-dimensional network structure. The tetranuclear complex II lies about a crystallographic inversion centre and has one core in which two CuII metal centers are mutually interconnected via two enolato oxygen atoms while the other two CuII cations are linked by a chloride anion and an enolato oxygen. An open-cube structure is generated in which the two open-cube units, with seven vertices each, share a side composed of two CuII ions bridged by two enolato oxygen atoms acting in a μ3-mode. The CuII atoms in each of the two CuO3NCl units are connected by one μ2-O and two μ3-O atoms from deprotonated hydroxyl groups and one chloride anion to the three other CuII centres. Each of the pentacoordinated CuII cations has a distorted NO3Cl square-pyramidal environment. The CuII atoms in each of the two CuO2NCl2 units are connected by μ2-O and μ3-O atoms from deprotonated alcohol hydroxy groups and one chloride anion to two other CuII ions. Each of the pentacoordinated CuII cations has a distorted NO2Cl2 square-pyramidal environment. In the crystal, a series of intramolecular C—H...O and C—H...Cl hydrogen bonds are observed in each tetranuclear monomeric unit, which is connected to four tetranuclear monomeric units by intermolecular C—H...O hydrogen bonds, thus forming a planar two-dimensional structure in the (\overline{1}01) plane.

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“…The tetranuclear rhenium (I) complex [Re(µ-H)Re] + [Re(µ-OR) 3 Re] -, 2 is structurally unique and different from the known tetranuclear rhenium (I) molecular rectangles [9,10], cyclic tetranuclear platinum (II) and palladium (II) [13], ruthenium (II) [14], copper(II) [15], silver (I) [16], tin(IV) [17] and a whole host of related other tetranuclear metal complexes. Anticancer properties of numerous mono and dinuclear and a few trinuclear rhenium (I) complexes are known [18][19][20][21][22][23][24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

A Novel Organometallic Rhenium Salt: DNA-Binding and Cytotoxicity Studies on Pancreatic, Breast and Lymphoma Cancers

Krauss¹,

Varisli²,

Winstead³

et al. 2021

Preprint

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DNA-binding studies of a variety of rhenium(I) tricarbonyl complexes are known. Primarily the rhenium complexes bind to DNA through intercalation or minor groove or both. We synthesized a novel organometallic salt of the type, [Re(µ-H)Re]+[Re(µ-OR)3Re]-. The UV-vis and emission spectroscopic titrations and viscosity studies indicate that the salt binds to DNA through partial intercalation. A variety of mono-, di-, and trinuclear rhenium(I) carbonyl complexes are known to exhibit cytotoxicity against numerous cancer cell lines. Examples of the cytotoxicity of tetranuclear rhenium (I) tricarbonyl complexes are rare. We have found that the tetranuclear, novel organometallic salt is highly potent on numerous cancer cells. The IC50 values (concentrations required to induce 50% cell deaths) are 0.220 µM on BxPC-3 pancreatic cancer cells, 0.298 µM on estrogen receptor positive MCF-7 breast cancer cells, 0.948 µM on triple negative MDA-MB-231 breast cancer cells, and 0.300 µM on U-937 lymphoma cells.

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A new tetranuclear copper(II) complex using a Schiff base ligand: Synthesis, structural, and magnetic studies

Cited by 9 publications

References 67 publications

A trinuclear copper (II) complex of naproxen‐appended salicylhydrazide: Synthesis, crystal structure, DNA binding and molecular docking study

A trinuclear copper (II) complex of naproxen‐appended salicylhydrazide: Synthesis, crystal structure, DNA binding and molecular docking study

A Novel Organometallic Rhenium Salt: DNA-Binding and Cytotoxicity Studies on Pancreatic, Breast and Lymphoma Cancers

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A new tetranuclear copper(II) complex using a Schiff base ligand: Synthesis, structural, and magnetic studies

Cited by 9 publications

References 67 publications

A trinuclear copper (II) complex of naproxen‐appended salicylhydrazide: Synthesis, crystal structure, DNA binding and molecular docking study

A trinuclear copper (II) complex of naproxen‐appended salicylhydrazide: Synthesis, crystal structure, DNA binding and molecular docking study

Crystal structures of two CuII compounds: catena-poly[[chloridocopper(II)]-μ-N-[ethoxy(pyridin-2-yl)methylidene]-N′-[oxido(pyridin-3-yl)methylidene]hydrazine-κ4 N,N′,O:N′′] and di-μ-chlorido-1:4κ2 Cl:Cl-2:3κ2 Cl:Cl-dichlorido-2κCl,4κCl-bis[μ3-ethoxy(pyridin-2-yl)methanolato-1:2:3κ3

A Novel Organometallic Rhenium Salt: DNA-Binding and Cytotoxicity Studies on Pancreatic, Breast and Lymphoma Cancers

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