A new technique for double lung transplantation

Bisson, A; Bonnette, P.

doi:10.1016/s0022-5223(19)35063-9

Cited by 60 publications

(9 citation statements)

References 11 publications

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“…Single LTx was performed using a classic technique, 15 whereas bilateral LTx was a bilateral sequential operation. 16 Our policy was to perform single LTx except in case of significant bronchiectasis. Immunosuppression was administered as previously described.…”

Section: Organ Allocation and Transplantation Proceduresmentioning

confidence: 99%

Survival benefit of lung transplantation for patients with idiopathic pulmonary fibrosis

Thabut¹,

Mal²,

Castier³

et al. 2003

The Journal of Thoracic and Cardiovascular Surgery

219

130

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Section: Organ Allocation and Transplantation Proceduresmentioning

confidence: 99%

Survival benefit of lung transplantation for patients with idiopathic pulmonary fibrosis

Thabut¹,

Mal²,

Castier³

et al. 2003

The Journal of Thoracic and Cardiovascular Surgery

219

130

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“…Bilateral sequential lung transplant was performed in all four cases immediately after harvesting of the lungs to shorten the time of organ ischemia (16). Pancreatic islets were isolated using a modification of the automated Ricordi method in Geneva (17).…”

Section: %) and Numerous Hypoglycemic Episodes Despite Intensive Insmentioning

confidence: 99%

Combined Pancreatic Islet–Lung Transplantation: A Novel Approach to the Treatment of End‐Stage Cystic Fibrosis

Kessler¹,

Bakopoulou²,

Kessler³

et al. 2010

American Journal of Transplantation

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Patients with end-stage cystic fibrosis (CF) and severe CF-related diabetes (CFRD) may benefit from combined lung-pancreatic islet transplantation. In the present study, we report the long-term follow-up of four end-stage CF patients treated with combined bilateral lung and pancreatic islet transplantation from the same donor. All patients were C-peptide negative (<0.5 lg/L) and inadequately controlled despite intensive insulin treatment. One patient was transplanted with 4 019 ± 490 islet equivalent/kg injected into the transverse colic vein using a surgical approach. In the remaining three patients, islets were cultured for 3-6 days and transplanted by percutaneous transhepatic catheterization of the portal vein. In all patients, islet allograft recovery was recognized by elevation in the plasma level of C-peptide (>0.5 lg/L). At 6 months after transplantation, one patient showed multiple episodes of acute lung transplant rejection and a progressive decline in pancreatic islet cell function. Three out of four patients experienced an improved control of glucose levels with a HbA1c of 5.2%, 7% and 6% respectively at 1.5, 2 and 15 years follow-up. Compared with the pretransplant period, there was a 50% reduction in mean daily insulin needs. Pulmonary function remained satisfactory in all patients. In conclusion, our cases series shows that combined bilateral lung and pancreatic islet transplantation may be a viable therapeutic option for patients with end-stage CF and CFRD.

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“…Surgery consisted of bilateral sequential single lung transplantation performed through an anterior bithoracosternotomy incision, as described previously. 1 TOE monitoring continued throughout the surgical procedure to assess haemodynamic status and the arterial and venous vascular anastomoses. 2 At the ®nal perioperative TOE examination, performed before skin closure, an echo-dense mass, 34 mm wide, was detected, attached to the pulmonary artery catheter in the right atrium (Fig.…”

Section: Case Reportmentioning

confidence: 99%

Probable allergic reaction to cyclosporin and early formation of thrombi on a pulmonary artery catheter: two unusual complications during bilateral lung transplantation

Dalibon

Stern

Bonnette

et al. 2002

British Journal of Anaesthesia

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We describe a patient who had two rare complications (a probable allergic reaction to cyclosporin and the early formation of a right atrial thrombus) during bilateral sequential single lung transplantation performed under the one anaesthetic. The thrombus, discovered at the end of the procedure, was then removed under cardiopulmonary bypass. Peroperative transoesophageal echocardiography was useful in providing critical diagnostic and therapeutic information.

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A new technique for double lung transplantation

Cited by 60 publications

References 11 publications

Survival benefit of lung transplantation for patients with idiopathic pulmonary fibrosis

Survival benefit of lung transplantation for patients with idiopathic pulmonary fibrosis

Combined Pancreatic Islet–Lung Transplantation: A Novel Approach to the Treatment of End‐Stage Cystic Fibrosis

Probable allergic reaction to cyclosporin and early formation of thrombi on a pulmonary artery catheter: two unusual complications during bilateral lung transplantation

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