A New Technique for Detection of Microbes in the Body and for Chemotherapeutic Evaluation of Antibacterial Agents : Whole Body Bacterioautography

Sakuma, Mari; Sato, Yoshishige

doi:10.1248/yakushi1947.89.12_1740

Cited by 1 publication

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“…The autobacteriographic images of nonmedicated mice with systemic staphylococcal infections coincided well with the images provided in previous reports (16,17). In these mice, a high density of microbes was arranged in a clumplike fashion on the external surfaces of organs.…”

Section: Methodssupporting

confidence: 87%

“…The medium conditions used in the original method for autobacteriography (16,17) were modified as follows, for the oral antibiotics used in this study, to avoid antibiotic diffusion from the gastrointestinal tract in whole-body sections (Y. Kohno, K. Ohta, T. Suwa, and T. Suga, J. Antimicrob. Chemother., in press).…”

Section: Methodsmentioning

confidence: 99%

“…To evaluate the potency of antimicrobial agents against experimentally infected animals, Sakuma et al (16)(17)(18) and Tani et al (20) proposed the unique method of whole-body autobacteriography and demonstrated its advantages after the administration of various antimicrobial agents. By this method, one can semiquantitatively follow the distribution and localization of pathogenic microbes on the whole-body section of host animals and can visualize it in a single photograph.…”

mentioning

confidence: 99%

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Autobacteriographic studies of clarithromycin and erythromycin in mice

Kohno

Ohta

Suwa

et al. 1990

Antimicrob Agents Chemother

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The antimicrobial activity of clarithromycin was compared with that of erythromycin in experimentally infected mice by whole-body autobacteriography. In mice with systemic staphylococcal infections, the number of vital microbes in the body was relatively low in the early period after oral administration of erythromycin, but increased thereafter to the levels found in nonmedicated control mice. On ['4Clerythromycin, particulary in the lungs. The observations described above indicate the superior in vivo antimicrobial activity of clarithromycin compared with that of erythromycin and suggest that the superiority of clarithromycin is largely attributed to its favorable distribution properties. The advantages of whole-body autobacteriography, coupled with whole-body autoradiography, are discussed.

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Section: Methodssupporting

confidence: 87%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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