A New Tactile Skin Sensor for Measuring Skin Hardness in Patients with Systemic Sclerosis and Autoimmune Raynaud's Phenomenon

Takei, Masami; Shiraiwa, Hidetaka; Omata, Sadao; Motooka, N; Mitamura, Ko; Horie, Takashi; Ookubo, Takao; Shibata, Shigeki

doi:10.1177/147323000403200217

Cited by 20 publications

(14 citation statements)

References 18 publications

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“…In addition, the system has been applied to the measurement of the hardness of skin, muscle, and cartilage in laboratory experiments and even in clinical evaluations. [16][17][18][19] Because the hardness of the distraction callus we measured was between the soft tissue and cartilage, we thought that this technique was valid in our study. The biosensor has a natural oscillating piezoelectric element and detects the change in frequency produced by the contact of the sensor with the tenting material as hardness.…”

Section: Distraction-callus Hardness Measurementmentioning

confidence: 92%

Stimulation of EP4 receptor enhanced bone consolidation during distraction osteogenesis

Chang

Mishima

Ishii

et al. 2006

Journal Orthopaedic Research

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The objective of this study was to confirm whether an agonist of prostaglandin E receptor subtype EP4 can enhance bone consolidation in distraction osteogenesis. A rat distraction osteogenesis model was generated. A unilateral external fixator was fixed to the left femur of the rats of this model after osteotomy. Seven days later, 0.25 mm/12 h or 0.5 mm/12 h elongation was performed for 2 weeks. A systemic administration of an EP4 receptor agonist (ONO 4819 Á CD, 3, 10, 30 mg/kg) or normal saline by subcutaneous injection was also performed for 2 weeks. The animals were sacrificed 10, 14, 17, 21, and 42 days after the operation. Radiographic examination, histological examination, and measurements of bone mineral density (BMD) and distraction-callus hardness were performed to qualitatively and quantitatively evaluate new bone formation. Twenty-one days after the operation, the experimental group had a higher BMD and a higher distraction-callus hardness than that of the control group. Forty-two days after the operation, BMD was similar among all of the groups. But the hardness of the experimental groups increased more than that of the control group, so the statistical differences in distraction-callus hardness became more distinct between the two groups, indicating an improved remodeling of the distraction callus. These findings are also supported by histological examination. Subcutaneous injection of an EP4 receptor agonist can promote bone formation and remodeling during distraction osteogenesis. ONO 4819 Á CD might be a potential candidate for shortening the treatment time of distraction osteogenesis. ß

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Section: Distraction-callus Hardness Measurementmentioning

confidence: 92%

Stimulation of EP4 receptor enhanced bone consolidation during distraction osteogenesis

Chang

Mishima

Ishii

et al. 2006

Journal Orthopaedic Research

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“…Hence, the restoration of reaction force feedback and tactile information is needed for safer and more accurate robotic surgery. In order to realize the haptic feedback, many types of haptic master and tactile device have been proposed [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21]. However, RMIS systems with reaction force or tactile feedback showed limited performance.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies on tactile devices that can be integrated with haptic masters have been performed for robot surgery [16,17]. However, these studies have also identified difficulty in realizing the various sensations of human organs by touching sensors.…”

Section: Introductionmentioning

confidence: 99%

Material Characterization of Hardening Soft Sponge Featuring MR Fluid and Application of 6-DOF MR Haptic Master for Robot-Assisted Surgery

Sohn

Choi

2018

Materials

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In this work, the material characterization of hardening magneto-rheological (MR) sponge is analyzed and a robot-assisted surgery system integrated with a 6-degrees-of-freedom (DOF) haptic master and slave root is constructed. As a first step, the viscoelastic property of MR sponge is experimentally analyzed. Based on the viscoelastic property and controllability, a MR sponge which can mimic the several reaction force characteristics of human-like organs is devised and manufactured. Secondly, a slave robot corresponding to the degree of the haptic master is manufactured and integrated with the master. In order to manipulate the robot motion by the master, the kinematic analysis of the master and slave robots is performed. Subsequently, a simple robot cutting surgery system which is manipulated by the haptic master and MR sponge is established. It is then demonstrated from this system that using both MR devices can provide more accurate cutting surgery than the case using the haptic master only.

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“…[171013] A tactile resonance sensor developed by Lindahl and Omata has yielded results similar to those achieved by palpation[11] and has already been used in studies assessing the stiffness of soft tissues. [31416] The stiffness of living tissue can be quantitatively derived from elasticity and viscosity in mechanical analysis, and hence measurement of elasticity with a tactile resonance sensor placed on an external decompression may be an objective measure of brain stiffness. Overall brain stiffness is derived from the stiffness of the pia-arachnoid, gray matter, white matter, cerebrospinal fluid (CSF), and cerebral blood vessels.…”

Section: Introductionmentioning

confidence: 99%

Edema and elasticity of a fronto-temporal decompressive craniectomy

Takada

Nagai²,

Moritake³

et al. 2012

Surg Neurol Int

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Background:Decompressive craniectomy is undertaken for relief of brain herniation caused by acute brain swelling. Brain stiffness can be estimated by palpating the decompressive cranial defect and can provide some relatively subjective information to the neurosurgeon to help guide care. The goal of the present study was to objectively evaluate transcutaneous stiffness of the cranial defect using a tactile resonance sensor and to describe the values in patients with a decompressive window in order to characterize the clinical association between brain edema and stiffness.Methods:Data were prospectively collected from 13 of 37 patients who underwent a decompressive craniectomy in our hospital during a 5-year period. Transcutaneous stiffness was measured as change in frequency and as elastic modulus.Results:Stiffness variables of the decompressive site were measured without any adverse effect and subsequent calculations revealed change in frequency = 101.71 ± 36.42 Hz, and shear elastic modulus = 1.99 ± 1.11 kPa.Conclusions:The elasticity of stiffness of a decompressive site correlated with brain edema, cisternal cerebrospinal fluid pressure, and brain shift, all of which are related to acute brain edema.

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A New Tactile Skin Sensor for Measuring Skin Hardness in Patients with Systemic Sclerosis and Autoimmune Raynaud's Phenomenon

Cited by 20 publications

References 18 publications

Stimulation of EP4 receptor enhanced bone consolidation during distraction osteogenesis

Stimulation of EP4 receptor enhanced bone consolidation during distraction osteogenesis

Material Characterization of Hardening Soft Sponge Featuring MR Fluid and Application of 6-DOF MR Haptic Master for Robot-Assisted Surgery

Edema and elasticity of a fronto-temporal decompressive craniectomy

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