A new synthetic route to substituted cyclam macrocycles

Two solvatomorphic forms of a copper complex formulated as Cu(L1)(ClO4)2·1.2H2O and Cu(L1)(ClO4)2, whereL1is 3,10-C-meso-3,5,7,7,10,12,14,14-octamethyl-1,4,8,11-tetraazacyclotetradecane

“…Saturated tetraaza macrocycles have proven to be versatile macrocyclic ligands capable of forming stable inert complexes with a variety of biomedically important metal ions, the chemistry of which has attracted interest due to their involvement in a variety of catalytic, biochemical and industrial processes (Kimura et al, 1992(Kimura et al, , 1994. Regarding biological applications, metal complexes of the 14-membered tetraaza macrocyclic ligands directly relevant to the present study have been explored for their use in magnetic resonance imaging (MRI) and radioimmunotherapy (Norman et al, 1995;Konig et al, 1996). They are also useful in terms of their utility in pharmacological (Hollinshead & Smith, 1990), crystal engineering (Suh et al, 2006) and analytical (Singh et al, 1999) endeavours, and they have been found to have antifungal ( 2007) and (in some cases) potential anticancer properties (Arai et al, 1998;Gao et al, 2010).…”

Syntheses, characterization and anti‐microbial activities of palladium(II) and palladium(IV) complexes of 3,10‐C‐meso‐Me8[14]diene (L1) and its reduced isomeric anes (LA, LB and LC). Crystal and molecular structure of [PdL1][Pd(SCN)4]

“…1. L 1 , L B , L C interact with PdCl 2 and K 2 Pd(SCN) 4 to produce square-planar palladium(II) (6), respectively. Moreover 1-4 were found to undergo ligand substitution reactions with KSCN to produce the thiocyanato complexes, 5-8, respectively.…”

“…1,2-Diaminopropane, HClO 4 , sodium borohydride (Merck Germany), PdCl 2 .xH 2 O (Aldrich, USA), KSCN, KNO 3 and KNO 2 (Fluka AG, Switzerland) were used as received from commercial sources. The solvents used in the reactions were of AR-grade and were obtained from commercial sources (Merck, Germany).…”

“…The anti-bacterial activity was expressed in terms of the diameter (in mm) of the zone of inhibition. 4 ] suitable for the X-ray diffraction study were prepared by slow crystallization of a DMSO-acetonitrile (3 : 1) solution of the compound. Intensity data were collected at 153 K on a Rigaku AFC12/Saturn724 CCD fitted with Mo Kα radiation.…”

“…[1,2] In the realm of biological applications, metal complexes of compounds related to cyclam (14-membered tetraaza macrocyclic ligands) have been explored for their use in magnetic resonance imaging (MRI) and radioimmunotherapy. [3,4] They are also important for their applications in pharmacological, [5] industrial, [6] crystal engineering [7] and analytical [8] fields. Their importance also relates to their anti-fungal [9] and anti-bacterial [10,11] activities.…”