A New Synthetic Approach to (+)‐Hyacinthacine A₁ and the First Total Synthesis and Absolute Configuration Assignment of Naturally Occurring (+)‐Hyacinthacine A₆

Pyrrolizidine alkaloids

“…184 A further paper, describing the syntheses of (+)-hyacinthacine A 1 (401) and (+)-hyacinthacine A 6 (65), was retracted. 185 Desvergnes and Py prepared the hyacinthacine homologue '8-homo-ent-(+)-hyacinthacine A 2 ' (548, Scheme 86) from Dglucose as a potential UDP-galactopyranose mutase (UGM) inhibitor. 186 Octyl tetra-O-benzyl D-glucose was hydrolysed, exposing the 1,4-hydroxyaldehyde from which nitrone 546 was prepared by condensation and S N 2-displacement steps.…”