A New Synthesis of Oxazolo[5,4-d]pyrimid-7-ones

Synthesis and Biological Activity of Oxazolopyrimidines

“…Annulation of pyrimidine rings to 4-carboxy-5-aminooxazoles using a variety of one-carbon synthons. [42] Scheme 32. Ring closure to the desired oxazolopyrimidinones 187 was effectuated by a catalytic amount of sodium ethoxide in good overall yields.…”

“…Ring closure to the desired oxazolopyrimidinones 187 was effectuated by a catalytic amount of sodium ethoxide in good overall yields. [42] Unfortunately, the synthesis and characterization of these compounds was not described in detail.…”

“…These were subsequently cyclized to oxazolopyrimidin-7-ones 163 by treatment with ethanolic potassium hydroxide in very good yields. [42] Scheme 32. Synthesis of oxazolo [5,4-d]pyrimidin-7-ones through the Cornforth rearrangement, as reported by Maryanoff and co-workers.…”

“…Synthesis of oxazolo [5,4-d]pyrimidin-7-ones through the Cornforth rearrangement, as reported by Maryanoff and co-workers. [42]…”

Structure-Based Design of Inhibitors to the Cytotoxin Ricin

“…This route has some precedence in the literature, (Patil et al, 1971;Turchi et al, 1983;Sekeya et al, 1990) but no cases have been reported in which 2-amino-substituted heterocycles (such as 1) were formed. Our efforts have currently focused on intermediate 4-carboxy-5-ethoxyoxazoles.…”