A new synthesis of 2-fluoro-1-naphthols

Synthetic approaches to regiospecifically mono‐ and dilabelled arenes

“…These ethers are then converted to the respective naphthols by heating with a mixture of acetic acid and 48% HBr in good yields (Scheme ). As with the previous method, the source of the label is most likely to arise from the starting indanone rather than the carbene source 187…”

5-Hydroxyindan-1-one

“…For the spectroscopy of the title compound, see: Magnusson et al (1964). For the synthetic and biological applications on indanones, see: Cai et al (2005); De Paulis et al (1981); Howbert & Crowell (1990); Kwiecien et al (1991). For the preparation, see: Danishefsky et al (1979).…”

“…Acid strengths of 5-and 7-hydroxyindan-1-one have been investigated by UV-vis and 1 H NMR measurements (Magnusson et al, 1964). In addition, 1-indanones were important precursors in the regiospecific synthesis of 2-fluoro-1naphthols (Cai et al, 2005). 5-Chloro-1-indanone was used to synthesize important biomedical compounds as anticonvulsants (Kwiecien et al, 1991), and anticholinergics (De Paulis et al, 1981), showing great activity against solid tumours (Howbert et al, 1990).…”

5,6,7-Trimethoxy-2,3-dihydroinden-1-one

“…For background literature on indanones and their biological applications, see: Andreani et al (2000); Cai et al (2005); De Paulis et al (1981); Hanna & Lau-cam (1989); Howbert & Crowell (1990); Kwiecien et al (1991); Mithofer et al (2005); Omran et al (2005); Pinkerton et al (2005); Yamamoto et al (1994).…”

“…A number of donepezil analogues have been prepared with prospective in the treatment of Alzheimer disease (Andreani et al, 2000). 1-Indanones are also important precursors in the regiospecific synthesis of 2fluoro-1-naphthols (Cai et al, 2005). 5-Chloro-1-indanone has been used to synthesize important biomedical compounds as anticonvulsants (Kwiecien et al, 1991), anticholinergics (De Paulis et al, 1981) and diarylsulfonylureas, which show great activity against solid tumours (Howbert et al,1990).…”