A New Subtype of Human T-Cell Leukemia Virus (HTLV-II) Associated with a T-Cell Variant of Hairy Cell Leukemia

Vs, Kalyanaraman; Sarngadharan, M. G.; Robert-Guroff, Marjorie; Miyoshi, Isao; Golde, David W.; Gallo, Rosella

doi:10.1126/science.6981847

Cited by 1,080 publications

(432 citation statements)

References 17 publications

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“…Although both HTLV-I/II (34,35) and HTLV-III (36,37) can enter non-T4 + cells and integrate as proviral DNA, the pathologic effects of both types of viruses result primarily from their infection of T4 ÷ cells. HTLV-I, the etiologic agent of adult T cell leukemia (ATL) (38,39), transforms T4 + cells preferentially.…”

Section: Discussionmentioning

confidence: 99%

Regulation of T cell autocrine growth. T4+ cells become refractory to interleukin 2.

Gullberg¹,

Smith²

1986

The Journal of Experimental Medicine

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During the course of investigating the regulation of IL-2-dependent T cell proliferation, we found that the subset of human T cells expressing the T4 surface glycoprotein become refractory to IL-2 growth promotion earlier than T8+ cells. Since T4+ cells proliferate in an autocrine fashion to endogenous IL-2, whereas most T8+ cells respond in a paracrine fashion to IL-2 derived from T4+ cells, we thought it likely that a unique mechanism was operative to restrict T4+ cell IL-2-dependent autocrine proliferation. Moreover, we anticipated that the T4+ cell IL-2-refractory state related either to suppression by T8+ cells, or to expression of T4+ cell IL-2-R. However, several experimental approaches did not support either of these mechanisms as being responsible for the loss of T4+ cell IL-2 responsiveness. Isolated T4+ cells ceased to respond to IL-2 well before T8+ cells, and before the disappearance of adequate levels of IL-2-R. Moreover, a detailed comparison of IL-2-R expression by T4+ vs. T8+ cells revealed no differences in the number, affinity, rate of expression, or functional activity of high-affinity IL-2-R expressed by the two subsets. Accordingly, T4+ cell autocrine IL-2 responsiveness is restricted by a mechanism that is independent of IL-2-R, and which ultimately results in cessation of both T4+ and T8+ cell IL-2-dependent clonal expansion.

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Section: Discussionmentioning

confidence: 99%

Regulation of T cell autocrine growth. T4+ cells become refractory to interleukin 2.

Gullberg¹,

Smith²

1986

The Journal of Experimental Medicine

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“…HTLV-1 preferentially targets and transforms CD4+ T-cells and is the etiologic agent of adult T-cell leukemia (ATL) (Yoshida et al, 1982) and HTLV associated myelopathy/tropical spastic paraparesis (HAM/TSP) (Osame et al, 1986). HTLV-2 is much less pathogenic, but has been associated with a few cases of atypical hairy cell leukemia and neurological disease (Hjelle et al, 1992;Kalyanaraman et al, 1982). Elucidation of the mechanisms by which infection with these two viruses results in distinct outcomes will provide fundamental insights into the initiation of multistep leukemogenesis.…”

Section: Introductionmentioning

confidence: 99%

Detection and quantitation of HTLV-1 and HTLV-2 mRNA species by real-time RT-PCR

Green

2007

Journal of Virological Methods

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SummaryHTLV-1 and HTLV-2 are highly related delta-retroviruses that infect and transform T-lymphocytes, but have distinct pathogenic properties. HTLV replication and survival requires the expression of multiple gene products from an unspliced and a series of highly related alternatively spliced mRNA species. To date, the comparative levels of all known HTLV-1 and HTLV-2 viral mRNAs in different transformed cell lines and at different stages of virus infection have not been assessed. In this study, we compiled a series of oligonucleotide primer pairs and probes to quantify both HTLV-1 and HTLV-2 mRNA species using real-time RT-PCR. The optimized reaction for detection of each mRNA had amplification efficiency greater than 90% with a linear range spanning 25 to 2.5 × 10 7 copies. The R 2 s of all standard curves were greater than 0.97. Quantitation of HTLV mRNAs between different cell lines showed variability (gag/pol ≥ tax/rex > env ≥ accessory proteins), but the overall levels of each mRNA relative to each other within a cell line were similar. These results provide a method to quantify all specific mRNAs from both HTLV-1 and HTLV-2, which can be used to evaluate further viral gene expression and correlate transcript levels to key stages of the virus life cycle and ultimately, pathogenesis.

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“…As primeiras descrições desse vírus ocorreram na década de 80, nos Estados Unidos 79 80 e no Japão 38 39 e, desde então, novos conhecimentos acerca da infecção por esse agente surgiram 16 65 . A descrição inicial do vírus linfotrópico humano de células T do tipo 2 (HTLV-2) aconteceu em 1982, em paciente com leucemia de células pilosas 42 . Informações adicionais sobre o HTLV-2 podem ser obtidas em outro estudo 34 .…”

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Lesões dermatológicas em pacientes infectados pelo vírus linfotrópico humano de células T do tipo 1 (HTLV-1)

Nobre

Guedes

Proietti

et al. 2005

Rev. Soc. Bras. Med. Trop.

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RESUMO O vírus linfotrópico humano de células T do tipo 1 (HTLV-1) é o primeiro retrovírus isolado do ser humano. Descreveuse, em pouco tempo, o seu papel etiológico em algumas doenças, com destaque para a leucemia/linfoma de células T do adulto (ATLL), a mielopatia associada ao HTLV-1/paraparesia espástica tropical (HAM/TSP) e a uveíte associada ao HTLV-1 (HAU). Na década de 90, o HTLV-1 foi associado a eczema grave da infância, conhecido como dermatite infecciosa (DI). Desde então, diversos outros tipos de lesões cutâneas têm sido observados em pacientes infectados pelo HTLV-1, em especial, nos doentes de HAM/TSP ou de ATLL. Porém, mesmo portadores assintomáticos do vírus apresentam doenças dermatológicas. Excetuando-se a dermatite infecciosa, não há lesão da pele específica da infecção pelo HTLV-1. Aqui, os autores apresentam as principais lesões dermatológicas descritas em pacientes infectados pelo HTLV-1, destacando o valor epidemiológico e clínico desses achados. Palavras-chaves: HTLV-1. Retrovírus. ATLL. HAM/TSP. Lesões dermatológicas. Pele. ABSTRACT Human T-cell Lymphotropic vírus type I (HTLV-1) was the first human retrovírus described. Some time after its discovery a group of diseases were related to this vírus, such as, adult T-cell leukemia lymphoma (ATLL), HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and HTLV-1 associated uveitis (HAU). In the nineties, HTLV-1 was associated to a severe eczema of children, called infective dermatitis (ID

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A New Subtype of Human T-Cell Leukemia Virus (HTLV-II) Associated with a T-Cell Variant of Hairy Cell Leukemia

Cited by 1,080 publications

References 17 publications

Regulation of T cell autocrine growth. T4+ cells become refractory to interleukin 2.

Regulation of T cell autocrine growth. T4+ cells become refractory to interleukin 2.

Detection and quantitation of HTLV-1 and HTLV-2 mRNA species by real-time RT-PCR

Lesões dermatológicas em pacientes infectados pelo vírus linfotrópico humano de células T do tipo 1 (HTLV-1)

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