A New Strategy to Prepare Poly(2‐methyl‐2‐oxazoline)‐Based Antifouling Coatings: Using UV‐Crosslinked Copolymer Anchors

Abstract

A series of the copolymer, poly(styrene-random-glycidyl methacrylate) (P(Str-GMA)), is synthesized by free radical polymerization, and characterized by 1 H NMR spectroscopy and gel permeation chromatography. The various substrates are then modified by P(St-r-GMA) under ultraviolet (UV) irradiation. Subsequently, the poly(2-methyl-2-oxazoline) (PMOXA) based coatings are prepared by anchoring amino-terminated PMOXA onto the P(St-r-GMA) modified surfaces through the reaction between the amino group of PMOXA and epoxy group of P(St-r-GMA). The results of ellipsometry, X-ray photoelectron spectroscopy, atomic force microscopy, and water contact angle reveal that PMOXA-based coatings can be prepared successfully on the substrates through UV-crosslinked P(St-r-GMA) as anchoring coatings. Besides, the PMOXA-based coatings display not only a superior antifouling property but long-term stability as well. Furthermore, the location of the coating formed on the substrate can be well controlled through selecting the site of UV irradiation, which can be utilized for the selectivity of protein adsorption (or resistance) on special devices.

Poly(2‐oxazoline)s: a comprehensive overview of polymer structures and their physical properties—an update

“…PAOxs offer a large structural variability and associated variation in polymer properties for the construction of polymer material for biological and pharmaceutical applications, driven by their unique features, such as non-ionic nature, hydrophilicity, tunable thermal, solution and chemical properties along with high biocompatibility and stealth characteristics. Therefore, PAOxs have gained significant interest for various pharmaceutical and biomedical applications such as matrix excipients for oral drug formulation, 110,111 self-assembled nanocarriers/polymersomes for drug delivery, [112][113][114] polymer-protein [115][116][117] and polymer-drug conjugates, 118,119 anti-bacterial and anti-microbial agents, 82,83 anti-fouling surfaces, 120,121 and hydrogels and nanogels for drug/gene delivery. [122][123][124] Since the discovery of PAOx in 1966, the syntheses of more than 125 PAOx homopolymers with various side chain functionalities have been reported in the literature, either via CROP of newly designed 2-oxazoline monomers or through post-polymerization modification methods.…”

Thermoresponsive Poly(2-propyl-2-oxazoline) Surfaces of Glass for Nonenzymatic Cell Harvesting

“…Poly­(2-oxazoline)­s exhibit tunable physicochemical properties, favorable biocompatibility, and chemical stability, and they attract the growing attention of researchers. Poly­(2-methyl-2-oxazoline) and its derivatives have been applied to design antifouling interfaces because of their excellent antifouling performance and chemical stability. , Compared with poly­(ethylene glycol), the structure and function of poly­(2-oxazoline)­s are more tunable and variable; thus, poly­(2-oxazoline)­s can be applied to develop hemostatic dressings . Owing to the peptidomimetic structure, poly­(2-oxazoline)­s have stealth behavior in vivo, and a series of drug and gene delivery systems have been explored and verified. − However, there are only a few reports on the application of poly­(2-oxazoline) surfaces in nonenzymatic cell harvesting.…”

“…Poly(2-methyl-2oxazoline) and its derivatives have been applied to design antifouling interfaces because of their excellent antifouling performance and chemical stability. 24,25 Compared with poly(ethylene glycol), the structure and function of poly(2oxazoline)s are more tunable and variable; thus, poly(2oxazoline)s can be applied to develop hemostatic dressings. 26 Owing to the peptidomimetic structure, poly(2-oxazoline)s have stealth behavior in vivo, and a series of drug and gene delivery systems have been explored and verified.…”