A new strategy for treating colorectal cancer: Regulating the influence of intestinal flora and oncolytic virus on interferon

Yi, Jia; Lin, Peizhe; Li, Qingbo; Zhang, Ao; Kong, Xianbin

doi:10.1016/j.omto.2023.08.010

Cited by 2 publications

(1 citation statement)

References 207 publications

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“…Preclinical studies have shown a plausible relationship between intestinal flora and efficacy of oncolytic virus‐mediated immunotherapy. Yi et al, suggested that gut microbiota may synergistically increase the antitumoral activity of oncolytic virus via the common IFN‐mediated pathway in colorectal cancer [ 113 ]. What's more, the antitumor effect of oncolytic adenovirus Ad5D24‐CpG (Ad‐CpG) was recently found to at least partially attribute to gut microbiota, and Bifidobacterium supplementation could hamper tumor progression and intratumoral Treg infiltration in melanoma mice receiving Ad‐CpG treatment [ 114 ].…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota reshapes cancer immunotherapy efficacy: Mechanisms and therapeutic strategies

Xie,

Liu,

Deng

et al. 2024

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Gut microbiota is essential for maintaining local and systemic immune homeostasis in the presence of bacterial challenges. It has been demonstrated that microbiota play contrasting roles in cancer development as well as anticancer immunity. Cancer immunotherapy, a novel anticancer therapy that relies on the stimulation of host immunity, has suffered from a low responding rate and incidence of severe immune‐related adverse events (irAEs). Previous studies have demonstrated that the diversity and composition of gut microbiota were associated with the heterogeneity of therapeutic effects. Therefore, alteration in microbiota taxa can lead to improved clinical outcomes in immunotherapy. In this review, we determine whether microbiota composition or microbiota‐derived metabolites are linked to responses to immunotherapy and irAEs. Moreover, we discuss various approaches to improve immunotherapy efficacy or reduce toxicities by modulating microbiota composition.

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Section: Discussionmentioning

confidence: 99%