A New Strategy for Neurochemical Photodelivery:  Metal−Ligand Heterolytic Cleavage

Abstract

A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal-ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule is released by irradiation with visible light (>480 nm). The liberated 4AP promotes the activation of a leech neuron by means of blocking its K+ channels. The syntesis, characterization, and the inherent advantages of this method are discussed.

The photochemistry of transition metal complexes using density functional theory

“…These compounds are able to releases, with high yields, one of the monodentate ligands and were all, except the pyridine derivative, prepared by Etchenique and co-workers for the photorelease of neuroactive small molecules, i.e. 4-aminopyridine, butylamine and γ -aminobutyric acid [97][98][99].…”

Von Ein‐ zu Zwei‐Photonen‐Sonden: photoaktivierbare Reagentien, Aktuatoren und Photoschalter

“…[62] RuBiPy-Komplexe wurden zur Schützung von Amingruppen in verschiedenen Molekülen eingesetzt. [63] Reagentien dieser Art, z.…”

Synthesis And Characterization Of Nano Structured (4- Aminopyridine) Copper (Ii) Acetate Chloride

“…The first metal-base caged compound capable of releasing organic biomolecules was [Ru(bpy)2(4AP)2]2+, where 4AP is 4 aminopyridine, a K + (potassium ) channel blocker [1]. Only a few caged neurochemicals have been prepared so far using the metal coordination strategy, the technique has a promising future.…”